Hyperacute Rejection of Living Related Kidney Grafts Caused by Endothelial Cell-Specific Antibodies: Case Reports

Transplant Centre, Faculty Hospital, Martin, Slovakia.
Transplantation Proceedings (Impact Factor: 0.98). 10/2008; 40(7):2422-4. DOI: 10.1016/j.transproceed.2008.06.014
Source: PubMed


We describe two cases of hyperacute humoral rejection of living related kidney grafts despite negative pretransplantation T- and B-lymphocyte flow cytometric crossmatches and blood group identity. Retrospectively, antiendothelial IgG antibodies were detected on a panel of umbilical cord cells in the first case, and IgM antibodies against donor endothelial precursor cells were detected using a new endothelial cell crossmatch kit in the second case. Standard crossmatch methods using donor lymphocytes failed to detect these pathogenic antibodies and did not predict the danger of hyperacute rejection.

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