IL-4 in the Brain: A Cytokine To Remember

ArticleinThe Journal of Immunology 189(9):4213-9 · November 2012with23 Reads
Impact Factor: 4.92 · DOI: 10.4049/jimmunol.1202246 · Source: PubMed


    IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appears to operate in normal brain function, and propose a hypothesis concerning its potential role in neurological pathologies. The Journal of Immunology, 2012, 189: 4213-4219.