Humoral Immunity and Development of Obliterative Bronchiolitis Post Lung Transplantation - is there a Link?

Department of Medicine, Division of Pulmonary and Critical Care, Indiana University School of Medicine, Indianapolis, Indiana, United States.
American Journal of Respiratory Cell and Molecular Biology (Impact Factor: 3.99). 10/2012; 48(2). DOI: 10.1165/rcmb.2012-0349RT
Source: PubMed


Lung transplantation is considered a definitive treatment for many end stage lung diseases. However, the lung is rejected more commonly than other solid organ allografts. Obliterative bronchiolitis (OB) is the leading cause of chronic allograft dysfunction and the key reason why five year survival of lung transplant recipient is only 50%. The pathophysiology of OB is incompletely understood. While there is a clear role for immune response to donor antigens, also known as anti- human leukocyte antigens (anti-HLA), evidence is emerging about the role of autoimmunity to self antigens. This review will highlight the current understanding of humoral immunity in development of OB post lung transplantation.

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