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Exercise is brain food: The effects of physical activity on cognitive function



This commentary reviews selected biomedical and clinical research examining the relationship between physical exercise and cognitive function especially in youth with disability. Youth with physical disability may not benefit from the effects of exercise on cardiovascular fitness and brain health since they are less active than their non-disabled peers. In animal models, physical activity enhances memory and learning, promotes neurogenesis and protects the nervous system from injury and neurodegenerative disease. Neurotrophins, endogenous proteins that support brain plasticity likely mediate the beneficial effects of exercise on the brain. In clinical studies, exercise increases brain volume in areas implicated in executive processing, improves cognition in children with cerebral palsy and enhances phonemic skill in school children with reading difficulty. Studies examining the intensity of exercise required to optimize neurotrophins suggest that moderation is important. Sustained increases in neurotrophin levels occur with prolonged low intensity exercise, while higher intensity exercise, in a rat model of brain injury, elevates the stress hormone, corticosterone. Clearly, moderate physical activity is important for youth whose brains are highly plastic and perhaps even more critical for young people with physical disability.
Developmental Neurorehabilitation, July 2008; 11(3): 236–240
Exercise is brain food: The effects of physical activity
on cognitive function
Clinical Research, Rehabilitation Program, Eastern Health Authority, St. John’s, Newfoundland and Labrador,
(Received 15 January 2008; revised 29 January 2008; accepted 5 February 2008)
This commentary reviews selected biomedical and clinical research examining the relationship between physical exercise
and cognitive function especially in youth with disability. Youth with physical disability may not benefit from the effects of
exercise on cardiovascular fitness and brain health since they are less active than their non-disabled peers. In animal models,
physical activity enhances memory and learning, promotes neurogenesis and protects the nervous system from injury and
neurodegenerative disease. Neurotrophins, endogenous proteins that support brain plasticity likely mediate the beneficial
effects of exercise on the brain. In clinical studies, exercise increases brain volume in areas implicated in executive
processing, improves cognition in children with cerebral palsy and enhances phonemic skill in school children with reading
difficulty. Studies examining the intensity of exercise required to optimize neurotrophins suggest that moderation is
important. Sustained increases in neurotrophin levels occur with prolonged low intensity exercise, while higher
intensity exercise, in a rat model of brain injury, elevates the stress hormone, corticosterone. Clearly, moderate
physical activity is important for youth whose brains are highly plastic and perhaps even more critical for young people with
physical disability.
Keywords: Neurotrophin,neuroplasticity,brain-derived neurotrophic factor,BDNF,rehabilitation
Este comentario revisa investigaciones biome
´dicas y clı
´nicas selectas que examinan la relacio
´n entre el ejercicio fı
´sico y la
´n cognitiva, particularmente en jo
´venes con discapacidad. Los jo
´venes con alguna discapacidad fı
´sica pueden no
beneficiarse de los efectos del ejercicio en el cerebro y en el acondicionamiento del sistema cardiovascular, ya que son menos
activos que jo
´venes sin discapacidad. En modelos animales, la actividad fı
´sica estimula a la memoria y al aprendizaje,
promueve la neuroge
´nesis y protege al sistema nervioso de las lesiones y de las enfermedades neurodegenerativas. Las
neurotrofinas son proteı
´nas endo
´genas que apoyan a los procesos de plasticidad cerebral, y posiblemente median los efectos
´ficos del ejercicio sobre el cerebro. En estudios clı
´nicos el ejercicio aumenta el volumen cerebral en a
´reas implicadas en
el procesamiento ejecutivo, mejora la cognicio
´n en nin
˜os con para
´lisis cerebral, y aumenta la habilidad fone
´mica en nin
˜os en
edad escolar que tienen dificultad para la lectura. Los estudios que examinan la intensidad del ejercicio necesaria para
optimizar a las neurotrofinas sugieren que la moderacio
´n es importante. El ejercicio prolongado de baja intensidad produce
aumentos sostenidos en los niveles de las neurotrofinas, mientras que en un modelo experimental en ratas con lesio
cerebral, el ejercicio de alta intensidad mostro
´una elevacio
´n de la corticoesterona, que es la hormona del estre
Evidentemente la actividad fı
´sica moderada es importante para los jo
´venes cuyos cerebros son altamente pla
´sticos, y tal vez
´tica para jo
´venes con discapacidad fı
´sica. Tı
´tulo abreviado: El ejercicio es alimento cerebral.
Palabras clave:Neurotrofina,neuroplasticidad,factor neurotro
´fico de origen cerebral,BDNF,rehabilitacio
It is immediately recognized that exercise promotes
good health of the cardiovascular and musculoskele-
tal systems, however the field of exercise
and cognitive function is rapidly growing.
Unfortunately, youth with physical disability are
twice as likely to watch more than 4 hours of television
per day than young people without disability [1].
Correspondence: Michelle Ploughman, Clinical Research, Rehabilitation Program, Eastern Health Authority, L. A. Miller Centre, 100 Forest Road, St. John’s
Newfoundland and Labrador, Canada A1A 1E5. Tel: þ1709 777 2099. E-mail:
ISSN 1751–8423 print/ISSN 1751–8431 online/08/030236–5 ß2008 Informa UK Ltd.
DOI: 10.1080/17518420801997007
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As a result, inactive youth with disability not only
have lower cardiovascular and musculoskeletal fit-
ness, but do not avail of the cognitive benefits of
Studies in ageing humans show that endurance
exercise is protective against cognitive decline,
especially executive planning and working memory
[2–4]. In both humans [5–7] and primates [8],
exercise increases attention and performance on
cognitive tasks. In a rat model of stroke, running
exercise promotes neuronal dendritic branching and
enhances relearning of forelimb motor skill [9].
Currently there are three hypotheses explaining how
exercise may affect executive control. Exercise may
increase oxygen saturation [2] and angiogenesis [10]
in brain areas crucial for task performance. Kramer
et al. [2] found that walking exercise increased the
rate of oxygen consumption in healthy older adults
that was associated with improved reaction time and
enhanced performance in tests of executive function-
ing. The second hypothesis suggests that exercise
increases brain neurotransmitters, such as serotonin
and norepinephrine, facilitating information proces-
sing [11–13]. Increased levels of arousal, detected by
brain electroencephalogram (EEG), have been
measured in persons exercising at less than 70%
of their maximum oxygen capacity (considered
within the moderate training zone) [5, 7, 14].
The third, and probably most well-studied hypoth-
esis, is that exercise upregulates neurotrophins such
as brain-derived neurotrophic factor (BDNF),
insulin-like growth factor (IGF-I) and basic fibro-
blast growth factor (bFGF) that support neuronal
survival and differentiation in the developing brain
and dendritic branching and synaptic machinery in
the adult brain (for review see [15]). It is clear that
youth with physical disability, with brains ripe for
new learning and sometimes with concomitant
cognitive challenges, may require physical activity
even more than adults.
The important neurotrophins
To understand neurotrophins and how they support
the nervous system, one must understand the effects
of these endogenous substances on the neurons
themselves. Neurotrophins are proteins that have
classically been identified as mediators of neuronal
survival and differentiation during development.
Each neurotrophin regulates specific populations of
neurons during development; however, more
recently, neurotrophins have been shown to maintain
the viability of neurons in adulthood and protect and
restore neurons in response to injury and ageing.
Neurons are described as being ‘plastic’; the efficacy
of synaptic transmission is adaptable and neuro-
trophins serve as activity-dependent modulators of
synaptic plasticity [15]. Neurotrophins regulate
target genes which may encode structural proteins,
enzymes or neurotransmitters that result in
modification of neuronal morphology and function.
This ability for neuronal plasticity allows one to form
and retain memories and learn in all dimensions;
spatially, cognitively and motorically. The neurotro-
phin brain-derived neurotrophic factor (BDNF) has
emerged as a key mediator of synaptic plasticity in the
memory centre of the brain, the hippocampus [16].
Synaptic signalling and responsiveness are enhanced
within seconds of BDNF administration to rat
hippocampal neurons [17, 18]. BDNF also augments
the number of synapses and enhances axonal
branching within the cortex [17], thereby increasing
the potential synaptic contact sites [18]. When the
critical expression of BDNF is blocked within the rat
brain, the animals show impairments in memory and
learning [19, 20]. Importantly, physical activity in
rats increases BDNF, as well as genes that are
members of synaptic vesicle trafficking machinery
and parts of signalling pathways whose activity affects
synaptic function [21].
Exercise and neurogenesis
It was once believed that the adult brain was
incapable of producing new neurons. It is now
known that neurogenesis occurs in the hippocampus
and in the layer of cells surrounding the lateral
cerebral ventricles (the subventricular zone) and,
moreover, that exercise stimulates this proliferation
[22]. These cells are sometimes referred to as
endogenous stem cells. In a recent study [23],
examining the benefit of stem cells in a rat model
of stroke, exercise and enriched environment stimu-
lated migration of transplanted stem cells to the
injury site and enhanced sensorimotor recovery.
Physical activity may increase baseline neuronal
activity or neurotrophic support, providing the
necessary signals for these cells to integrate into
neuronal networks. Stem cells (both endogenous
and transplanted) and the influence of physical
activity in the developing brain is a promising area
of research that could benefit children with physical
and cognitive impairment.
Exercise enhances cognitive function
In rats, 1 week of voluntary exercise increases BDNF
and enhances performance on the Morris water
maze, a test of spatial memory in which rats must
remember the location of a submerged platform
[24]. These findings have been confirmed by others
in both the normal animal brain [25, 26] and the
brain altered by injury [9, 27]. There is evidence that
Exercise is brain food 237
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the exercise-cognition phenomenon exits in humans
as well, especially in young adults. Aerobic fitness in
children is associated with higher measures of
neuroelectric responsiveness (P3 amplitude in brain
evoked potentials), faster cognitive processing speed
[28] and better performance in a test of executive
control [29]. A meta-analysis confirmed the positive
relationship between physical activity and cognitive
and academic performance in school aged children
[30]. Even though level of physical activity can be
confounded by other factors such as IQ and socio-
economic status, these findings are convincing.
In a 2-year follow-up of a prospective randomized
controlled trial, Reynolds and Nicolson [31] deter-
mined that a 6 month home-based sensorimotor
programme enhanced school and reading perfor-
mance in 36 children with reading difficulty (some
with dyslexia). Daily home exercises focused on
cerebellar/vestibular challenge including balancing
on one leg, spinning, bouncing, standing on a
wobble board, tandem walking and throwing and
catching balls. Students demonstrated improve-
ments in reading accuracy, phonemic skill, verbal
working memory and reduction in inattention
symptoms as well as accelerated gains in standard
school performance tests. These findings suggest
that the benefits of exercise are not simply cardio-
vascular. The enrichment provided by physical
activity has a broad effect on seemingly unrelated
executive processing centres. Furthermore, a recent
study by Verschuren et al. [32] showed that a
45 minute programme (twice per week for 8 months)
not only improved aerobic capacity, strength and
function but significantly improved cognition
and quality of life in people with cerebral palsy
aged 7–20 years. Even more interesting is that 4
months after completing the programme, partici-
pants maintained the cognitive benefits while fitness
measures returned to baseline. These studies sup-
port the concept of an exercise-cognition interaction
in children with disabilities. Programmes that
increase physical activity and fitness in youth with
disability will also likely improve executive function.
Future studies examining the implementation of
physical activity programmes should not only mea-
sure physical fitness but include cognitive, emotional
and quality of life outcome measures as well.
Exercise protects the nervous system
Physical activity attenuates the memory and cogni-
tive decline associated with normal ageing and in
pathological conditions such as Alzheimer’s Disease
[33, 34]. Exercise has also been recently shown to
increase brain volume in healthy exercising adults. In
a study using magnetic resonance imaging (MRI) to
examine brain volume, 59 people aged 60–79 were
randomly assigned to aerobic or non-aerobic exer-
cise groups (1 hour three times a week for 6
months). Adults exercising aerobically showed
increased brain volume in frontal lobe regions
implicated in higher order processing, attentional
control and memory [35].
In a rodent model of stroke, 2 weeks of voluntary
running (0.8 km per day) preceding cerebral stroke
resulted in improved survival and sparing of neurons
in multiple brain regions [36]. Carro et al. [27] have
demonstrated convincingly that moderate exercise
(1 km per day) improves functional recovery and
saves neurons in a number of rodent injury models.
They examined hippocampal degeneration (vulner-
able in Alzheimer’s disease), brainstem injury and
hereditary cerebellar degeneration. Lesioned animals
that ran before brain injury had improved function
and spared neurons and animals running for 5 weeks
following injury, improved to 90% of controls.
Exercise maintained function and preserved
Purkinje cells in the cerebellum and prevented
ataxia in hereditary cerebellar degeneration.
Although research in the neuroprotective effects
of exercise in humans, especially young people,
is scarce, findings in biomedical research are
compelling. One wonders if people who are inactive
are less protected against neurological injury
and neurodegenerative disease.
How much exercise is enough?
If exercise is beneficial for the brain, the next logical
question is ‘How much exercise is enough?’ A recent
meta-analysis of 37 studies (1306 children, young
adults and older adults) suggests that although most
studies support that exercise has a positive effect on
cognitive performance, cardiovascular fitness (VO
Max) alone does not explain these benefits [37].
Exercise effects on executive function are not dose-
responsive, meaning that better fitness does not
necessarily lead to larger cognitive gains. In fact,
smaller gains in fitness are associated with larger
cognitive effect sizes. Studies in children with
reading difficulties also show that children received
cognitive benefits from a programme designed to
challenge balance, timing and co-ordination, rather
than cardiovascular fitness [31]. This suggests that
physical activity levels that benefit cognition may
not necessarily be as intense as those levels required
to increase cardiovascular fitness. However, some
studies support that intense rather than moderate
exercise [12, 13] enhances neurotransmitter levels
and improves executive performance. These con-
flicting findings may reflect differences in exercise
paradigms and outcome measures. The specific
238 M. Ploughman
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exercise-cognition effect threshold is not known and
warrants further study.
Our research, using an adult rat model of
stroke, examined varying parameters of running
exercise to optimize the effects of exercise on brain
neurochemistry. BDNF and other markers of
neuroplasticity within brain tissue were examined
after 30 and 60 minutes of either running or walking
on a motorized wheel along with 60 minutes on a
voluntary running wheel [38, 39]. Telemetry was
used to determine the intensity of exercise to help
translate findings to clinical practice. Although 60
minutes of motorized exercise resulted in a robust
and immediate increase in hippocampal BDNF,
long-term, lower intensity (as measured by heart
rate), voluntary exercise resulted in more prolonged
upregulation of BDNF (2 hours). The implication
for clinical rehabilitation is that frequent, intermit-
tent, low intensity training (that is realistic to
provide) as well as a single bout of running exercise
can increase hippocampal levels of BDNF creating a
favourable ‘neuroplastic milieu’ during recovery
from stroke. Even though exercise enhanced pro-
teins that may be beneficial to recovery of function
after stroke, serum corticosterone, a stress hormone,
was found to be elevated in response to all methods
of exercise but more so with the more intense
exercise regimens. Since corticosterone has been
implicated in downregulation of BDNF [40], this is
a concern and warrants caution acutely after brain
injury. For the clinician, the old adage ‘everything in
moderation’ appears to apply when prescribing
physical activity for brain health.
Clinical considerations
It is believed that in most societies today people are
less active than in previous generations. The effect of
this inactivity on brain health is yet to be determined.
Hillman et al. [41] state that physical activity during
childhood may optimize cortical development pro-
moting lasting changes in brain structure and
function, but for youth with disability, the greatest
challenge is to find ways to increase physical activity
[42]. Kang et al. [43] examined barriers to exercise in
146 youth, aged 12–19, with physical disabilities
attending wheelchair basketball camp. These young
people identified mainly logistical barriers including
lack of time, pain or discomfort, lack of a place to
exercise with peers, weather and people’s misconcep-
tions of their abilities. Adults administered the same
tool complained more of psychological barriers to
exercise (lack of time, motivation, self-discipline).
These barriers may be overcome by an individually
tailored approach to exercise prescription such as
PEP-for-youth [42] and health providers must
emphasize, for their young clients, the multiple
benefits of physical activity on brain and body health.
Declaration of interest: The author reports no
conflicts of interest. The author alone is responsible
for the content and writing of the paper.
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... Attention study has aroused great interest in recent years in this context, as well as well as in the field of cognitive abilities [2,5]. Exploring how attention is related to physical sport activity practice is relevant because it is an essential cognitive capacity for human functioning, and it is also linked to other cognitive skills that facilitate the processes of adaptation to the environment [6][7][8]. Among other issues, attention contributes to the selection and appropriate processing of information, facilitating effective responses such as elaboration and execution [4]. ...
... Thus, there are some studies that suggest that, in fast ball sports, such as volleyball, women would benefit from a higher cognitive level because of their sport experience [50]. As can be seen in the aforementioned studies, all of them suggest that the impact of physical sports activity on cognitive development is not an aspect modulated by gender, but modulated by the amount and type of sports practice performed, as well as training time [7,51]. ...
Full-text available
Many studies have highlighted the impact of sport on cognitive functioning. However, more evidence is needed to explain which type of sport is more relevant. The main purpose of this study was to determine the level of attention span based on the type of sport practiced (open vs. closed). In addition, this problem was also analyzed based on gender and training hours. The study sample consisted of 547 participants (27.20% male; 72.80% female), aged between 19 and 35 years old (M = 24.19; SD = 3.74). The “Modrian Images” computerized test, hosted in MenPas Cell software(MenPas 1.0), was used to assess the attention span. The results showed that athletes playing open sports have a better attentional span than others playing closed sports. Moreover, this was also replicated when assessing by gender. Likewise, a greater number of hours in a week participating in sports is related to a better level of attentional span, being less determinant than the type of sport practiced. Data obtained suggest that playing open sports would be more related to the greater development of attention span than playing more closed sports.
... In our study, rats in the Ud and C groups had longer escape delays than the RT and Ud+RT groups, indicating poor learning ability in the Ud and C groups, and superiority in the RT and Ud+RT groups. Researchers believe that exercise may strengthen the structure of the hippocampus in animals [28]. Based on the reports of Voss et al., exercise (aerobic and resistance) increases the level of neurotrophins in the hippocampus of animals, which can be one of the reasons for the increase in the volume of the hippocampus. ...
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Introduction: Inflammation and oxidative stress are two major factors in accelerating brain aging. Consumption of some traditional herbs with antioxidant and anti-inflammatory properties such as Urtica dioica extract (Ud) and resistance training (RT) may be effective in controlling premature aging and memory impairment. Therefore, we hypothesized that the combined effect of RT and Ud might play an essential role in preventing memory disorders and hippocampal tissue changes caused by increasing age in rats. Methods: 28 male Wistar rats (24-week) were divided into 4-groups (n = 7): control (C), Ud, RT, and Ud+RT. RT groups were trained for five weeks, and Ud extract in the 0.0166 w/v concentration (50 mg/kg, oral/daily) was administered. We also examined the effects of RT and Ud on the behavioral (memory and learning), histological (the morphological changes in the dentate gyrus), and transcript aspects of hippocampal tissue. Results: Aging led to karyopyknosis in the hippocampal tissue, which was alleviated by RT and Ud supplementation. RT and Ud were accompanied by increased GPx, GSH, GAP-43, and decreased CAP-1 levels in the hippocampus. Moreover, RT and Ud led to increased NGF, BDNF, and GAP-43 levels, decreased MDA, and protection of hippocampal tissue from karyopyknosis, which was associated with cognitive improvement. However, these interventions had no significant effect on the hippocampal levels of IL-1β, SOD, and CAT. Conclusions: These findings suggest that increasing age decreases hippocampal NGF, BDNF, and GAP-43 levels and impairs cognition, which may be reversed by regular RT and Ud extract.
... The findings with a medium effect size provide evidence for the conceptual model, which hypothesized that the mechanisms explaining the association between physical activity, cognition and mental health in young people might be neurobiological, psychosocial and/or behavioral, and might be affected by the indicators of physical activity Barth Vedøy et al., 2020). The effects of physical activity on mental health can be explained by physiological indicators, such as cerebral blood flow and arousal levels (Querido and Sheel, 2007), neurotransmitters (Ploughman, 2008), the growth and plasticity of neurons (Hassevoort et al., 2016), and measures of brain function related to executive function (Donnelly and Lambourne, 2011). Results were similar to another study, it showed that increased physical activity levels and fitness can help alleviate or relieve depression, anxiety and stress by improving bone and musculoskeletal function (Eveland-Sayers et al., 2009). ...
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This study explored the association between out-of-school physical activity (PA) and mathematical achievement in relation to mathematical anxiety (MA), as well as the influence of parents’ support for their children’s physical activity on this association, to examine whether parental support for physical activity affects mental health and academic performance. Data were collected from the responses of 22,509 (52.9% boys) children in Grade 4 from six provinces across eastern, central, and western China who completed the mathematics component and the physical education and health component of the national-level education quality assessment. A moderated moderated-mediation model was tested using PROCESS v3.4 and SPSS v19.0, with socioeconomic status, school location, and body mass index as controlled variables. Out-of-school physical activity had a positive effect on children’s mathematical achievement, and math anxiety partially mediated this association. The indices of conditional moderated mediation through the parental support of both girls and boys were, respectively, significant, indicating that children can benefit from physical activity, and that increased perceived parental support for physical activity can alleviate their children’s math anxiety and improve their mathematics, regardless of gender. However, gender differences were observed in the influence of parental support for physical activity on anxiety: Although girls’ math anxiety levels were significantly higher, the anxiety levels of girls with high parental support were significantly lower than those of boys with low parental support.
... A group of nonathletes was recruited as a control group to strengthen our findings by isolating the influence of the independent variable, which, in this 305 particular case, was the participants' athletic experiences in open-and closedskill modalities. We expected that athletes would be superior when compared to sedentary individuals in terms of visual search ability, working memory, and reasoning due to the functional and structural changes in the executive processing areas of the cerebral cortex (Colcombe et al., 2006;Ploughman, 2008). ...
The degree to which each sport modality relies on cognitive visual skills is hitherto under-researched. This study sought to further understanding of the relationship between sport modality and visual search ability, visual working memory, and reasoning. Ninety-five participants took part in the present study. In order to assess visual search ability, we employed the Visual Search Task. Visual working memory was assessed through the Corsi Block Tapping – Backwards Task. Reasoning abilities were assessed through the Cognitive Reflection Task. Results indicate that visual search skills appear to benefit to a higher extent from open-skill sports when compared to closed-skill sports. It is important to emphasize, however that this result was associated with a small effect size. Moreover, the present findings indicate that closed-skill athletes do not differ in terms of visual search abilities, working memory, and reasoning abilities when compared to control individuals.
... The reported associations between physical fitness and cognitive performance as well as the impact of physical exercise programs on cognitive performance are most likely caused by increased brain oxygenation based on an increased blood flow [12]. In addition, an increased neurotransmitter concentration which encourage information processing and an enhanced growth factor concentration which stimulate brain plasticity and neuronal cell connectivity are possible explanations how physical activity and exercise may effect cognitive performance [13,14]. Thereby, the preschool age plays a decisive role during maturation. ...
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Abstract Background Given that recent studies report negative secular declines in physical fitness, associations between fitness and cognition in childhood are strongly discussed. The preschool age is characterized by high neuroplasticity which effects motor skill learning, physical fitness, and cognitive development. The aim of this study was to assess the relation of physical fitness and attention (including its individual dimensions (quantitative, qualitative)) as one domain of cognitive performance in preschool children. We hypothesized that fitness components which need precise coordination compared to simple fitness components are stronger related to attention. Methods Physical fitness components like static balance (i.e., single-leg stance), muscle strength (i.e., handgrip strength), muscle power (i.e., standing long jump), and coordination (i.e., hopping on one leg) were assessed in 61 healthy children (mean age 4.5 ± 0.6 years; girls n = 30). Attention was measured with the “Konzentrations-Handlungsverfahren für Vorschulkinder” [concentration-action procedure for preschoolers]). Analyses were adjusted for age, body height, and body mass. Results Results from single linear regression analysis revealed a significant (p
... Recent studies have demonstrated that the energy status of the body affects the expression of BDNF gene in the ventromedial hypothalamus of rats. Studies have also indicated that glucose injection, which prolongs hyperglycemia and hyperinsulinemia, acts like high-fat diet regarding the expression of BDNF gene; that is, it reduces the expression of this gene in the same part of the brain as does high-fat diet [20]. Considering the relationship between obesity and cognitive disorder, it is particularly important to investigate BDNF isoforms in the population of obese people and evaluate the effects of the designed strategies on minimizing disorders in performing executive functions. ...
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Obesity is the underlying cause of various health conditions such as hypertension, diabetes, and respiratory diseases. It is associated with low self-confidence, emotional disorder, anxiety, depression, social isolation, and suicide. In the present study, we investigated the effect of functional training on obese women's brain-derived neurotrophic factor (BDNF) and executive functioning. To this end, 25 obese women were randomly assigned to 3 different groups labelled as active obese women-functional training, inactive obese women-functional training, and control group. The subjects performed 24 one-hour-long sessions of functional training three times a week. The intensity of activity for the research groups was moderate, which was equivalent to a level of 6-7 on the Borg scale. The analysis of intragroup results indicated that functional training increased serum BDNF significantly in both active and inactive obese women. It was also observed to improve executive functioning in both groups of the obese women via decreasing the number of errors, increasing the number of true responses, and reducing reaction time. The analysis of intergroup results, on the other hand, revealed that there were no significant differences between active and inactive obese women in terms of serum BDNF and executive functioning after functional training. Training promotes cognitive health, and this study adds that functional training may be important for improvement and maintenance of brain health and functional performance. Therefore, by increasing BDNF level through functional exercises, it is possible to help improve the cognitive functions of obese women.
According to the United Nations Convention on the Rights of the Child (CRC), every child has a right to practise sports in a healthy, safe environment (art. 19). However, research indicates that child athletes experience various forms of violence in sports. Violence is particularly harmful to children, as the effects may be significant and long lasting. In addition, children often have difficulty identifying and reacting to violence. In this article, we first aim to shed light on the prevalence and implications of violence towards child athletes in sports. By child athletes, we mean athletes under the age of 18 (CRC art. 1). Thereafter, we discuss the following questions: (1) How does the CRC protect children in sports? (2) Can children’s rights be effectively protected through sports self-regulation of sports bodies and legal remedies? (3) Who is responsible for safeguarding children’s rights in sports? To answer these questions, we employ a multidisciplinary perspective that combines jurisprudence and sport psychology. In summary, we conclude that the CRC unequivocally prohibits all violence against children in all sectors of society, including sports. The responsibility for enforcing this prohibition lies with both member states and sports bodies. It is always the responsibility of adults. The full realisation of children’s rights requires action on multiple fronts, including legislation, information, education and resources.
Objectives This study aimed to understand whether an enriched environment (EE) in adulthood benefits in mitigating the early life stress-induced changes in the structure and functions of the hippocampus and amygdala. Materials and Methods Male Wistar rats were exposed daily for 6 h to early maternal separation and isolation (MS) stress from postnatal days (PND) 4–14 and later at PND 60–70 days subjected to EE, while, the normal control (NC) rats were not subjected to stress but reared with the mother under standard housing conditions. The effects of MS and EE on adulthood behaviour were not subjected to stress but assessed by measuring the ambulatory, repetitive and anxiety-like behaviour. The study has also done the plasma corticosterone concentrations. The dendritic remodelling in the amygdala and hippocampus was assessed using the Golgi cox staining approach. Finally, the present study compared the reactive oxygen species-induced lipid peroxidation and total antioxidant capacity in MS rats as an indirect measure of oxidative stress to study the impact of MS stress on the limbic circuit and peripheral organs. Results MS rats showed increased anxiety and lower plasma corticosterone levels. The pyramidal neurons’ dendritic plasticity displayed a different pattern, with shrinkage in the CA1 hippocampal neurons and hypertrophy in the amygdala’s primary neurons. Variations in antioxidant activity and peroxidation observed in NC to MS across tissues indicate the occurrence and management of oxidative stress in MS. The 10 days of EE in young adulthood helped to reduce MS stress-induced structural abnormalities in hippocampal and amygdala pyramidal neurons, as well as anxiety and plasma corticosterone levels. Conclusion These findings together indicate that exposure to adverse experiences may cause harmful effects on brain plasticity and behaviour in young adulthood. Exposure to EE may be beneficial in reducing the early life stress-induced pathophysiology later in life.
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44 ، ‫العدد‬ 4 ، 7102-700-© 7102 ‫اجلودة‬ ‫وضمان‬ ‫العلمي‬ ‫البحث‬ ‫عمادة‬ / ‫األردنية‬ ‫اجلامعة‬. ‫حمفوظة‬ ‫احلقوق‬ ‫مجيع‬. ‫البدني‬ ‫النشاط‬ ‫ممارسة‬ ‫نحو‬ ‫اليرموك‬ ‫بجامعة‬ ‫البدنية‬ ‫اللياقة‬ ‫مساق‬ ‫طلبة‬ ‫اتجاهات‬ ‫طلفاح‬ ‫سليمان‬ ‫شافع‬ ، ‫يعقوب‬ ‫حسين‬ ‫محمود‬ * ‫م‬ ‫لخ‬ ‫ـ‬ ‫ص‬ ‫التعرف‬ ‫اسة‬ ‫الدر‬ ‫هدفت‬ ‫إلى‬ ‫طلبة‬ ‫اتجاهات‬ ‫ب‬ ‫اللياقة‬ ‫مساق‬ ‫نحو‬ ‫اليرموك‬ ‫جامعة‬ ‫الشخصية‬ ‫ات‬ ‫للمتغير‬ ً ‫تبعا‬ ‫البدني‬ ‫النشاط‬ ‫ممارسة‬ (‫الكلية‬ ‫اسية،‬ ‫الدر‬ ‫السنة‬ ‫الجنس،‬ .) ‫من‬ ‫اسة‬ ‫الدر‬ ‫عينة‬ ‫وتكونت‬ ‫الوصفي،‬ ‫المنهج‬ ‫الباحثان‬ ‫استخدم‬ ‫و‬ (61) ‫وطالبة‬ ً ‫طالبا‬ (40) ‫من‬ ‫و‬ ‫الذكور‬ (21) ‫الجامعي‬ ‫للعام‬ ‫الثاني‬ ‫اسي‬ ‫الدر‬ ‫الفصل‬ ‫في‬ ‫البدنية‬ ‫اللياقة‬ ‫مساق‬ ‫في‬ ‫ا‬ ‫سجلو‬ ‫ممن‬ ‫االناث‬ ‫من‬ (2015) ‫اختيارهم‬ ‫تم‬ ‫ائية‬ ‫العشو‬ ‫يقة‬ ‫بالطر‬. ‫هما‬ ‫قسمين‬ ‫على‬ ‫االداة‬ ‫اشتملت‬ ‫حيث‬ ‫اسة،‬ ‫للدر‬ ‫كأداة‬ ‫االستبيان‬ ‫باستخدام‬ ‫البيانات‬ ‫جمع‬ ‫تم‬ : ‫ات‬ ‫المتغير‬ ‫االول‬ ‫طلبة‬ ‫اتجاهات‬ ‫لقياس‬ ‫استبيان‬ ‫الثاني‬ ‫و‬ ‫الشخصية‬ ‫مساق‬ ‫اللياقة‬ ‫البدنية‬ ‫ب‬ ‫من‬ ‫مكون‬ ‫البدني‬ ‫النشاط‬ ‫ممارسة‬ ‫نحو‬ ‫اليرموك‬ ‫جامعة‬ (73) ‫هي‬ ‫مجاالت‬ ‫بعة‬ ‫ار‬ ‫على‬ ‫موزعة‬ ‫ة‬ ‫فقر‬ (‫في‬ ‫المعر‬ ‫الجانب‬ ‫النفسي،‬ ‫الجانب‬ ‫االجتماعي،‬ ‫الجانب‬ ‫الصحي،‬ ‫الجانب‬ .) ‫وتم‬ ‫اختبار‬ ‫و‬ ‫المئوية‬ ‫النسب‬ ‫و‬ ‫ات‬ ‫ار‬ ‫التكر‬ ‫و‬ ‫ية‬ ‫المعيار‬ ‫افات‬ ‫االنحر‬ ‫و‬ ‫الحسابية‬ ‫المتوسطات‬ ‫باستخدام‬ ‫البيانات‬ ‫تحليل‬ (t) ‫المستقلة‬ ‫للعينات‬ ‫التباين‬ ‫وتحليل‬ (ANOVA). ‫ال‬ ‫اظهرت‬ ‫وقد‬ ‫اتجاهات‬ ‫بان‬ ‫نتائج‬ ‫اسة‬ ‫الدر‬ ‫عينة‬ ‫البدني‬ ‫النشاط‬ ‫ممارسة‬ ‫نحو‬ ‫بدرجة‬ ‫جاءت‬ ‫متوسطة‬. ‫ات‬ ‫لمتغير‬ ‫تعزى‬ ‫البدني‬ ‫النشاط‬ ‫ممارسة‬ ‫نحو‬ ‫الطلبة‬ ‫اتجاهات‬ ‫في‬ ‫احصائية‬ ‫داللة‬ ‫ذات‬ ‫فروق‬ ‫وجود‬ ‫وعدم‬ (‫الجنس‬ ‫الكلية‬ ‫و‬ ‫اسية‬ ‫الدر‬ ‫السنة‬ ‫و‬ .) ‫باألنشطة‬ ‫اليرموك‬ ‫جامعة‬ ‫طلبة‬ ‫مشاركة‬ ‫ة‬ ‫بضرور‬ ‫الباحثان‬ ‫اوصى‬ ‫و‬ ‫اللياقة‬ ‫مساقات‬ ‫خالل‬ ‫من‬ ‫البدنية‬ ‫الجنس‬ ‫اختالف‬ ‫على‬ ‫البدنية‬ ‫السنة‬ ‫و‬ ‫اسية‬ ‫الدر‬ ‫االجتماعية‬ ‫و‬ ‫النفسية‬ ‫و‬ ‫الصحية‬ ‫انب‬ ‫الجو‬ ‫على‬ ‫ايجابية‬ ‫ات‬ ‫تأثير‬ ‫من‬ ‫لها‬ ‫لما‬ ‫الكلية‬ ‫و‬ ‫المعرفية‬ ‫و‬. ‫الدالة‬ ‫الكلمات‬ : ‫البدنية،‬ ‫اللياقة‬ ‫االتجاهات،‬ ‫البدني‬ ‫النشاط‬ .
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The purpose of this study was to quantitatively combine and examine the results of studies pertaining to physical activity and cognition in children. Studies meeting the inclusion criteria were coded based on design and descriptive characteristics, subject characteristics, activity characteristics, and cognitive assessment method. Effect sizes (ESs) were calculated for each study and an overall ES and average ESs relative to moderator variables were then calculated. ESs (n = 125) from 44 studies were included in the analysis. The overall ES was 0.32 (SD = 0.27), which was significantly different from zero. Significant moderator variables included publication status, subject age, and type of cognitive assessment. As a result of this statistical review of the literature, it is concluded that there is a significant positive relationship between physical activity and cognitive functioning in children.
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Purpose: The authors investigated perceived exercise and physical activity barriers of active youth with physical disabilities. Research Method/Design: A 46-item exercise barrier instrument was administered to 145 youth (117 boys and 28 girls, 12 to 19 years of age). Using the Rasch model, the authors estimated barrier severity and youths' exercise perseverance. Model-data fit was determined by Infit and Outfit statistics (>= 0.5 and <= 1.5). Results: Except for I item, the model fit the data well. The most difficult barriers that youth with physical disabilities faced were lack of time and pain or discomfort. The older youth demonstrated higher exercise perseverance than the younger youth. There were no differences in youths' exercise perseverance scores by gender or National Wheelchair Basketball Association classification. Implications: Removing severe barriers should be a part of future exercise and physical activity interventions targeting this population.
Brain-derived neurotrophic factor (BDNF) regulates both short-term synaptic functions and activity-dependent synaptic plasticity such as long-term potentiation. In the present study, we investigated the role of BDNF in the spatial reference and working memory in a radial arm maze test. The radial arm maze training resulted in a significant increase in the BDNF mRNA expression in the hippocampus, although the expression in the frontal cortex did not change. When spatial learning was inhibited by treatment with 7-nitroindazole, an inhibitor of brain nitric oxide synthase, the increase in the hippocampal BDNF mRNA did not occur. To clarify the causal relation between BDNF mRNA expression and spatial memory formation, we examined the effects of antisense BDNF treatment on spatial learning and memory. A continuous intracerebroventricular infusion of antisense BDNF oligonucleotide resulted in an impairment of spatial learning, although the sense oligonucleotide had no effect. Treatment with antisense, but not sense, BDNF oligonucleotide was associated with a significant reduction of BDNF mRNA and protein levels in the hippocampus. Furthermore, treatment with antisense BDNF oligonucleotide in rats, which had previously acquired spatial memory by an extensive training, impaired both reference and working memory. There were no differences in locomotor activity, food consumption, and body weight between the antisense and sense oligonucleotide-treated rats. These results suggest that BDNF plays an important role not only in the formation, but also in the retention and/or recall, of spatial memory.
In the ageing process, neural areas¹,² and cognitive processes³,⁴ do not degrade uniformly. Executive control processes and the prefrontal and frontal brain regions that support them show large and disproportionate changes with age. Studies of adult animals indicate that metabolic⁵ and neurochemical⁶ functions improve with aerobic fitness. We therefore investigated whether greater aerobic fitness in adults would result in selective improvements in executive control processes, such as planning, scheduling, inhibition and working memory. Over a period of six months, we studied 124 previously sedentary adults, 60 to 75 years old, who were randomly assigned to either aerobic (walking) or anaerobic (stretching and toning) exercise. We found that those who received aerobic training showed substantial improvements in performance on tasks requiring executive control compared with anaerobically trained subjects.
Health promotion strategies for youth with physical disabilities are needed to reduce their high risk of acquiring secondary disabilities in adulthood. Many secondary disabilities are associated with lifestyle habits and are potentially preventable. To determine their health promotion needs, the Health Behaviours in School-aged Children, a WHO Cross-national Study questionnaire, was administered to 101 youth with physical disabilities. Their responses were compared with youth in a Canadian national sample. In comparison with the national sample, youth with physical disabilities reported that they were equally healthy, but experienced higher frequency of symptoms of poor health such as headaches, stomachaches and backaches. With respect to lifestyle health behaviours they were less likely to smoke, drink alcohol and use marijuana than their counterparts in the national sample. Youth with physical disabilities reported less healthy diets, less exercise and more sedentary leisure activities. These findings support the need for health promotion strategies tailored to the particular pattern of risks for youth with physical disabilities.
Preischemic spontaneous locomotor activity was distinguished in this laboratory as a factor influencing outcome after 15 and 20 minutes of forebrain ischemia in gerbils. Histological investigations were carried out to analyze potential relations between postischemic survival and a reduction of cerebral damage by spontaneous locomotor activity. Male Mongolian gerbils were divided into two groups, one with access to running wheels ("runners") and one kept in conventional cages ("nonrunners") for 2 weeks preceding forebrain ischemia of 15 or 20 minutes. A total of 99 gerbils were divided in subgroups and were allowed to recover for 2 weeks for assessment of survival. Other subgroups (n = 7 to 9) were killed at day 4 for quantitative histology of selectively vulnerable areas such as hippocampus, cortex, striatum, and thalamus. Two weeks after 15-minute ischemia, 44% of non-runners had survived compared with 90% of runners (P < .01). With 20-minute ischemia all runners survived compared with 21% of nonrunners. Quantitative histology (15-minute ischemia) revealed selective nerve cell injury in various cerebral regions in both groups. In runners, however, with the exception of the CA1 sector, damage was attenuated in cortex, striatum, and hippocampus. Furthermore, the extent of thalamic infarction was reduced (P < .05). Locomotor activity before global cerebral ischemia is highly efficient in protecting the brain as demonstrated by enhanced survival and a reduction of tissue damage in Mongolian gerbils. The mechanisms underlying this protection are currently unclear. However, further understanding of this intriguing phenomenon should enhance the understanding of ischemia pathophysiology and lead to the development of new treatment strategies.