This article examines the association between hypnotic suggestibility and treatment outcome in the context of various psychological and medical conditions including hypnotic analgesia, smoking cessation, post-traumatic stress disorder, dissociation, asthma, wart remission, eating disorders, obesity, somatization, and psychosis. In no case was high hypnotic suggestibility associated with negative treatment outcome, and in the case of pain management, hypnotic suggestibility has been shown to optimize treatment outcomes. Disorders in which findings regarding the link between suggestibility and treatment outcome are mixed yet promising include smoking cessation, obesity, wart remission, anxiety, somatization, and asthma. Methodological issues and potential mediators of the association between suggestibility and treatment outcome are discussed. (PsycINFO Database Record (c) 2012 APA, all rights reserved)