Risk of Pancreatitis According to Alcohol Drinking Habits: A Population-based Cohort Study

National Institute of Public Health, Oster Farimagsgade 5a, DK-1399 Copenhagen K, Denmark.
American journal of epidemiology (Impact Factor: 5.23). 09/2008; 168(8):932-7. DOI: 10.1093/aje/kwn222
Source: PubMed


The association between alcohol intake and pancreatitis has been examined previously in case-control studies, mostly consisting of men. The significance of beverage type and drinking pattern is unknown. The objective of this study was to assess the association between amount, type, and frequency of alcohol intake and risk of pancreatitis. For this purpose, the authors used data on 17,905 men and women who participated in the Copenhagen City Heart Study in 1976-1978, 1981-1983, 1991-1994, and 2001-2003 in Copenhagen, Denmark. Alcohol intake and covariates were assessed by questionnaire. Information on pancreatitis was obtained from national registers. A high alcohol intake was associated with a higher risk of pancreatitis. Hazard ratios associated with drinking 1-6, 7-13, 14-20, 21-34, 35-48, and >48 drinks/week were 1.1 (95% confidence interval (CI): 0.8, 1.6), 1.2 (95% CI: 0.8, 1.8), 1.3 (95% CI: 0.8, 2.1), 1.3 (95% CI: 0.7, 2.2), 2.6 (95% CI: 1.4, 4.8), and 3.0 (95% CI: 1.6, 5.7), respectively, compared with 0 drinks/week (P(trend) < 0.001). Associations were similar for men and women. Drinking frequency did not seem to be independently associated with pancreatitis.

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    • "A more recent study of the same authors reported that the amount of alcohol consumed per day was greater in spirit drinkers, suggesting that the higher alcohol consumption may be associated with the higher risk of pancreatitis [23]. The latest population-based cohort study of Kristiansen et al. [24] analysed a hazard ratio of 2.0 for the development of pancreatitis with drinking of more than 14 glasses of beer/week, whereas no association was observed for wine and spirits. However, this study was limited due to only a few participants with a high consumption (≥14 drinks/week) of both wine and spirits (eight and eight drinks/week, respectively) versus 49 drinks/week for beer. "
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