Article

Cancer Cell Metabolism: Warburg and Beyond

Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology Department of Biology, Cambridge, MA 02142, USA.
Cell (Impact Factor: 32.24). 10/2008; 134(5):703-7. DOI: 10.1016/j.cell.2008.08.021
Source: PubMed

ABSTRACT

Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg effect and establish a framework for understanding its contribution to the altered metabolism of cancer cells.

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