Self-Immolative Polymers

School of Pharmacy, University of Nottingham, Nottingham, UK.
Angewandte Chemie International Edition (Impact Factor: 11.26). 09/2008; 47(41):7804-6. DOI: 10.1002/anie.200802474
Source: PubMed


(Figure Presented) This message will self-destruct! Polymers that can be triggered to disassemble in a sequential fashion following a single triggering event were described recently. The amplification effect after cleavage of an end group by an enzyme leads to the spontaneous fragmentation of the polymer and the release of fluorescent reporters. The significance of these systems in terms of enzyme detection and drug release is discussed.

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