Red Cell Distribution Width and Mean Platelet Volume in Amyloidosis

Clinical and Applied Thrombosis/Hemostasis (Impact Factor: 2.39). 10/2012; 20(3). DOI: 10.1177/1076029612462761
Source: PubMed


We aimed to determine whether red cell distribution width (RDW) and mean platelet volume (MPV) values differ between patients with reactive amyloid A (AA) amyloidosis due to chronic inflammatory disease and in healthy participants. In this study, 33 patients with AA amyloidosis and 40 age- and sex-matched healthy controls were enrolled. Erythrocyte sedimentation rate (ESR), RDW, platelet count (PLT), and MPV levels were retrospectively obtained from our computerized patient database. We found RDW, ESR, and PLT levels to be significantly higher in patients with AA amyloidosis compared with the controls (P < .0001). Mean platelet volume was significantly lower in patients with amyloidosis (P < .0001). Inflammatory diseases such as AA amyloidosis may demonstrate low MPV and high RDW levels.

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    • "Researchers have found RDW values have positive correlation for serum bilirubin levels, prothrombin time and creatinine levels and negative correlation with serum albumin concentrations in liver disease[20]. A study comparing AA amyloidosis patients with a healthy control group found RDW values were significantly increased[21]. To our knowledge there is no study in the literature on RDW values in RPL cases. "

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