Intervention with flaxseed and borage oil supplements modulates skin condition in women

Institut für Biochemie und Molekularbiologie I, Heinrich-Heine-Universität Düsseldorf, P.O. Box 101007, D-40001 Düsseldorf, Germany.
The British journal of nutrition (Impact Factor: 3.45). 09/2008; 101(3):440-5. DOI: 10.1017/S0007114508020321
Source: PubMed


Ingestion of selected nutrients modulates dermal properties. In the present study, two groups of women ingested flaxseed or borage oil for 12 weeks. The control group received a placebo containing medium-chain fatty acids. Dose was 2.2 g total fatty acids/d with alpha-linolenic acid and linoleic acid as major constituents in the flaxseed oil group; in the borage oil group linoleic and gamma-linolenic acid were predominant. In the flaxseed oil group, the contribution of alpha-linolenic acid to total fatty acids in plasma was significantly increased on weeks 6 and 12, whereas there was an increase in gamma-linolenic acid in the borage oil group (P < 0.05). Skin irritation was performed by nicotinate treatment, and changes in skin reddening and blood flow were monitored. Compared to week 0, skin reddening was diminished in both groups; blood flow was also lowered. Skin hydration was significantly increased after 12 weeks of treatment compared to week 0, with flaxseed or borage oil (P < 0.05). Transepidermal water loss was decreased in both oil groups by about 10 % after 6 weeks of supplementation. A further decrease was determined after 12 weeks in the flaxseed oil group. Surface evaluation of living skin revealed that roughness and scaling of the skin were significantly decreased with flaxseed and borage oil comparing week 0 and week 12 (P < 0.05). Except for hydration, none of the parameters was affected in the placebo group. The present data provide evidence that skin properties can be modulated by an intervention with dietary lipids.

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Available from: Helmut Sies, Dec 17, 2013
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    • "The main sources of the GLA are borage and evening primrose [6] [7] . Borage produces 300 to 600 kg seed in Britain so as to increase the amount of GLA in available crops and produce GLA in common oilseed productions [7] [8] . Ninety percent of selling rate of GLA oil is related to evening primrose. "
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    ABSTRACT: Borage (Borago officinalis) is an annual herb which is cultivated for medicinal and culinary uses, although it is commercially cultivated for borage seed oil. Borage seed oil is the plant rich in the gamma-linolenic acid (26%-38%) which is used as dietary or food supplement. Other than seed oil it contains a lot of fatty acids such as linoleic acid (35%-38%), oleic acid (16%-20%), palmitic acid (10%-11%), stearic acid (3.5%-4.5%), eicosenoic acid (3.5%-5.5%) and erucic acid (1.5%-3.5%). It is used for the treatment of various diseases such as multiple sclerosis, diabetes, heart diseases, arthritis and eczema. In this study different aspects of borage such as plant characteristics, production, applications in traditional medicine, clinical considerations, its effects on patients' blood and urine biochemistry, and also the effect of the its products on liver and kidney performance tests are presented using published articles in scientific sites.
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    • "Two symmetrical regions of the cheeks were evaluated. Skin hydration was measured by using a corneometer (CM 825, Courage & Khazaka Electronics)( 10 , 11 ). Malar skin elasticity was measured by an absorption method (Cutometer SEM575, Courage & Khazaka Electronics)( 11 , 12 ). "
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    • "It is among the oldest crop plants cultivated for the purpose of oil and fiber (Millam et al., 2005). Furthermore, there is a report that flax products are also recommended for treating skin disease (e.g healing of chronic skin ulceration) (De Spirt et al., 2008). Flax oil is one of the richest sources of α-linoleic acid (α-LA), which includes about 44 to 57% of all fatty acids and it also contains 15 to 29% linolenic acid and 13 to 29% oleic acid (Muir and Westcott, 2003). "

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