Central amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates

Departments of Psychology and Psychiatry and HealthEmotions Research Institute, University of Wisconsin, Madison, WI 53719.
Proceedings of the National Academy of Sciences (Impact Factor: 9.67). 10/2012; 109(44). DOI: 10.1073/pnas.1206723109
Source: PubMed


Children with anxious temperament (AT) are particularly sensitive to new social experiences and have increased risk for developing anxiety and depression. The young rhesus monkey is optimal for studying the origin of human AT because it shares with humans the genetic, neural, and phenotypic underpinnings of complex social and emotional functioning. In vivo imaging in young monkeys demonstrated that central nucleus of the amygdala (Ce) metabolism is relatively stable across development and predicts AT. Transcriptome-wide gene expression, which reflects combined genetic and environmental influences, was assessed within the Ce. Results support a maladaptive neurodevelopmental hypothesis linking decreased amygdala neuroplasticity to early-life dispositional anxiety. For example, high AT individuals had decreased mRNA expression of neurotrophic tyrosine kinase, receptor, type 3 (NTRK3). Moreover, variation in Ce NTRK3 expression was inversely correlated with Ce metabolism and other AT-substrates. These data suggest that altered amygdala neuroplasticity may play a role the early dispositional risk to develop anxiety and depression.

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Available from: Patrick H Roseboom
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    • "The aim of the present study is to examine enduring BI-related alterations in amygdala iFC in a sample of young adults who were initially assessed as infants. Based on work in animal models of BI (Birn et al., 2014; Fox et al., 2012; Shackman et al., 2013) and human studies (Hardee et al., 2013), we predict that adults with a childhood history of BI will show alterations in amygdala iFC with insula and dlPFC. To examine the unique impact of BI on amygdala circuitry, independent of anxious pathology, we only included participants without current or lifetime anxiety diagnoses in our analyses. "
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