Effect of pioglitazone and rosiglitazone on mediators of endothelial dysfunction, markers of angiogenesis and inflammatory cytokines in type-2 diabetes. Acta Diabetol

Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Acta Diabetologica (Impact Factor: 2.4). 09/2008; 46(1):27-33. DOI: 10.1007/s00592-008-0054-7
Source: PubMed


The purpose of this study was to assess the effects of PPAR-gamma agonists (pioglitazone and rosiglitazone) on mediators of endothelial dysfunction and markers of angiogenesis in patients with type-2 diabetes. Pioglitazone group showed favorable reductions in serum total cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol and increase in HDL cholesterol as compared to rosiglitazone group, after 16 weeks of treatment and also with control group. There was significant reduction of CRP level in pioglitazone and rosiglitazone group. The level of serum TNF-alpha decreased significantly in pioglitazone and mildly decreased in rosiglitazone group. The level of VEGF, IL-8 and Angiogenin were increased in pioglitazone than rosiglitazone group. There were no significant changes observed in the serum angiogenin and IL-8 levels in the control group. Pioglitazone and rosiglitazone therapy in type-2 diabetes subjects have additional benefits of reducing mediators of endothelial dysfunction. Increase in angiogenesis markers in patients receiving pioglitazone could have variable effects in diabetic nephropathy and retinopathy as there may be increased vascular neogenesis. Pioglitazone has advantage over rosiglitazone in lowering lipid and proinflammatory cytokines.

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    • "We therefore could not exclude the possible influence of antidiabetic medications on the association of CRP with cigarette smoking and type 2 diabetes. However, previous studies have found that some antidiabetic medications affect the inflammatory response [39, 40]. Although we made a great effort to increase the response rate, a low response rate could not be avoided in the healthy population. "
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    • "Pioglitazone effect on glucose and lipid homeostasis, acquiesce with previous studies, [40]–[42], as well as its ability to increase adiponectin and to suppress TNF-α, and ALT [43]–[45]. Most of these actions are attributed to the effect of TZDs on PPARγ, as they activate multiple gene cassettes by their robust binding to this nuclear receptor; findings that support our docking results. "
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