A Genomewide Linkage Scan for Quantitative Trait Loci Influencing the Craniofacial Complex in Baboons (Papio hamadryas spp.)

Lifespan Health Research Center, Department of Community Health, Boonshoft School of Medicine, Wright State University, Dayton, Ohio 45420, USA.
Genetics (Impact Factor: 5.96). 09/2008; 180(1):619-28. DOI: 10.1534/genetics.108.090407
Source: PubMed


Numerous studies have detected significant contributions of genes to variation in development, size, and shape of craniofacial traits in a number of vertebrate taxa. This study examines 43 quantitative traits derived from lateral cephalographs of 830 baboons (Papio hamadryas) from the pedigreed population housed at the Southwest National Primate Research Center. Quantitative genetic analyses were conducted using the SOLAR analytic platform, a maximum-likelihood variance components method that incorporates all familial information for parameter estimation. Heritability estimates were significant and of moderate to high magnitude for all craniofacial traits. Additionally, 14 significant quantitative trait loci (QTL) were identified for 12 traits from the three developmental components (basicranium, splanchnocranium, and neurocranium) of the craniofacial complex. These QTL were found on baboon chromosomes (and human orthologs) PHA1 (HSA1), PHA 2 (HSA3), PHA4 (HSA6), PHA11 (HSA12), PHA13 (HSA2), PHA16 (HSA17), and PHA17 (HSA13) (PHA, P. hamadryas; HSA, Homo sapiens). This study of the genetic architecture of the craniofacial complex in baboons provides the groundwork needed to establish the baboon as an animal model for the study of genetic and nongenetic influences on craniofacial variation.

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    • "For at least one of these QTL, a likely causal variant (in BMP3) was identified. In primates, two studies also used GWAS and linear measurements from lateral cephalograms to map QTL responsible for the CF traits in baboons and humans, respectively (Sherwood et al., 2008, 2011). In a recent human GWAS, five candidate genes affecting facial shape variation in Europeans were identified (Liu et al., 2012). "
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