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Antifungal effect of silver nanoparticles on dermatophytes

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Keuk-Jun Kim at Taekyeung College
Keuk-Jun Kim
  • Taekyeung College
Woo Sang Sung
Woo Sang Sung
Woo Sang Sung
  • This person is not on ResearchGate, or hasn't claimed this research yet.
Seok-Ki Moon
Seok-Ki Moon
Seok-Ki Moon
  • This person is not on ResearchGate, or hasn't claimed this research yet.
Jong-Soo Choi
Jong-Soo Choi
Jong-Soo Choi
  • This person is not on ResearchGate, or hasn't claimed this research yet.
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Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated. Nano-Ag showed potent activity against clinical isolates and ATCC strains of Trichophyton mentagrophytes and Candida species (IC80, 1-7 microg/ml). The activity of nano-Ag was comparable to that of amphotericin B, but superior to that of fluconazole (amphotericin B IC80, 1-5 microg/ml; fluconazole IC80, 10- 30 microg/ml). Additionally, we investigated their effects on the dimorphism of Candida albicans. The results showed nano-Ag exerted activity on the mycelia. Thus, the present study indicates nano-Ag may have considerable antifungal activity, deserving further investigation for clinical applications.
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