Antifungal effect of silver nanoparticles on dermatophytes

Department of Microbiology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea.
Journal of Microbiology and Biotechnology (Impact Factor: 1.53). 09/2008; 18(8):1482-4.
Source: PubMed


Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated. Nano-Ag showed potent activity against clinical isolates and ATCC strains of Trichophyton mentagrophytes and Candida species (IC80, 1-7 microg/ml). The activity of nano-Ag was comparable to that of amphotericin B, but superior to that of fluconazole (amphotericin B IC80, 1-5 microg/ml; fluconazole IC80, 10- 30 microg/ml). Additionally, we investigated their effects on the dimorphism of Candida albicans. The results showed nano-Ag exerted activity on the mycelia. Thus, the present study indicates nano-Ag may have considerable antifungal activity, deserving further investigation for clinical applications.

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Available from: Keuk-Jun Kim, Nov 13, 2014
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    • "Applying nanosilver to eradicate fungi also gives satisfying results. Studies have confirmed that silver nanoparticles are an effective and rapidly acting factor against a wide variety of common fungi, including genera such as Aspergillus[32], Candida[33], and Saccharomyces[18]. Moreover, it has been shown that silver nanoparticles show marked activity against yeast isolated from infected cow udders[34]. "
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    • "ranging from 1 to 100 nm. Silver nanoparticles represent a prominent nanoproduct with potential applications in medicine and hygiene because of the antibacterial effects (Lok et al., 2006; Kim et al., 2007; Ayala-Núñez et al., 2009) antiviral actions (Elechiguerra et al., 2005; Mehrbod et al., 2009) and antifungal activity (Kim et al., 2008a). They also promote wound healing by playing a role in cytokine modulation (Wong et al., 2009). "
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