Article

Expression of ERG protein, a prostate cancer specific marker, in high grade prostatic intraepithelial neoplasia (HGPIN): Lack of utility to stratify cancer risks associated with HGPIN

Pathology and Laboratory Medicine Institute Glickman Institute of Urology and Kidney, Cleveland Clinic, Cleveland, OH Department of Pathology and Urology, Emory University School of Medicine, Atlanta, GA Department of Pathology, New York University Langone Medical Center, New York, NY, USA Peking University, Health Science Center, Beijing, China.
BJU International (Impact Factor: 3.53). 10/2012; 110(11B). DOI: 10.1111/j.1464-410X.2012.11557.x
Source: PubMed

ABSTRACT

Study Type – Diagnosis (cohort)
Level of Evidence 2b
What's known on the subject? and What does the study add?
High grade prostatic intraepithelial neoplasia is a pre-malignant lesion to prostate cancer and is associated with 20%–25% risk of prostate cancer in subsequent repeat biopsies. ERG is a highly prostate-cancer-specific marker.
Expression of ERG is rare in isolated high grade prostatic intraepithelial neoplasia diagnosed in prostate biopsy and is not associated with cancer risk in subsequent repeat biopsies.

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Available from: Cristina Magi-Galluzzi, Nov 10, 2014
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