The application of mechanics to study pelvic floor prosthetic devices (ie, pessaries, biologic grafts, and synthetic meshes) is becoming more appreciated in the urogynecology field. Mechanics, within the context of prosthetic devices, refers to the ex vivo and in vivo mechanical behaviors of these devices, their structural properties, and how these factors collectively, in combination with their ... [Show full abstract] textile properties, impact the overall physical performance of prosthetic devices. This information is crucial as mechanics directly impacts biocompatibility and therefore, affects patient outcomes. This chapter will provide an overview of the mechanical function of prosthetic devices and introduce various tests (and their relevance) that have been used to examine the mechanics of these devices. Additionally, results from these tests and the clinical implications of them will be discussed. The mechanics of synthetic meshes used in pelvic organ prolapse and stress urinary incontinence will be the main focus of this text.