Photoexcitation of tumor-targeted corroles induces singlet oxygen-mediated augmentation of cytotoxicity. J Control Release 163:368

Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA. Electronic address: .
Journal of Controlled Release (Impact Factor: 7.71). 10/2012; 163(3). DOI: 10.1016/j.jconrel.2012.09.015
Source: PubMed


The tumor-targeted corrole particle, HerGa, displays preferential toxicity to tumors in vivo and can be tracked
via fluorescence for simultaneous detection, imaging, and treatment. We have recently uncovered an additional
feature of HerGa in that its cytotoxicity is enhanced by light irradiation. In the present study, we
have elucidated the cellular mechanisms for HerGa photoexcitation-mediated cell damage using fluorescence
optical imaging. In particular, we found that light irradiation of HerGa produces singlet oxygen, causing mitochondrial damage and cytochrome c release, thus promoting apoptotic cell death. An understanding of the
mechanisms of cell death induced by HerGa, particularly under conditions of light-mediated excitation, may
direct future efforts in further customizing this nanoparticle for additional therapeutic applications and enhanced

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    • "The results obtained by this catalyst outperform all previous reports in terms of absolute catalytic turnover numbers, selectivity, and catalyst stability. The potential of metallocorroles as PS was also demonstrated in several publications [38] [39]. "
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    ABSTRACT: The photodynamic effect, originally used in photodynamic therapy (PDT) for the treatment of different diseases, e.g. of cancer, has recently been introduced for the inactivation of bacteria. Mold fungi, which provoke health problems like allergies and diseases of the respiratory tract, are even more resistant and their biology is also very different. This study presents the development of four new photosensitizers, which, in combination with low doses of white light, inhibit the germination of mold fungi spores. Two of them even cause lethal damage to the conidia (spores) which are responsible for the spreading of mold fungi. The photoactivity of the newly synthesized corroles was obtained by their application on three different mold fungi: Aspergillus niger, Cladosporium cladosporoides, and Penicillium purpurgenum. To distinguish between inactivation of germination and permanent damage, the fungi were first incubated under illumination for examination of photosensitizer-induced growth inhibition and then left in darkness to test the survival of the conidia. None of the compounds displayed dark toxicity, but all of them attenuated or prevented germination when exposed to light, and the positively charged complexes induced a complete damage of the conidia.
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    ABSTRACT: Abstract Corroles have assumed an important place in tetrapyrrolic chemistry. This review highlights the reactivity features of meso-arylcorroles under different reaction conditions. Graphical Abstract
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    ABSTRACT: The outer shell of the adenovirus capsid comprises three major types of protein (hexon, penton base and fiber) that perform the majority of functions facilitating the early stages of adenovirus infection. These stages include initial cell-surface binding followed by receptor-mediated endocytosis, endosomal penetration and cytosolic entry, and intracellular trafficking toward the nucleus. Numerous studies have shown that the penton base contributes to several of these steps and have supported the development of this protein into a delivery agent for therapeutic molecules. Studies revealing that the fiber and hexon bear unexpected properties of cell entry and/or nuclear homing have supported the development of these capsid proteins, as well into potential delivery vehicles. This review summarizes the findings to date of the protein-cell activities of these capsid proteins in the absence of the whole virus and their potential for therapeutic application with regard to the delivery of foreign molecules.
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