Article

The Effect of Garlic Tablet on Pro-inflammatory Cytokines in Postmenopausal Osteoporotic Women: A Randomized Controlled Clinical Trial

1Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences , Yazd , Iran.
Journal of Dietary Supplements 10/2012; 9(4). DOI: 10.3109/19390211.2012.726703
Source: PubMed

ABSTRACT

Introduction:
Menopause is one of the important causes of osteoporosis which results from estrogen deficiency. In addition, some clinical and experimental evidence indicates that there is an association between increasing pro-inflammatory cytokine activity and postmenopausal bone loss. The purpose of this study was to determine the effect of garlic tablet on pro-inflammatory cytokines in postmenopausal osteoporotic women.

Methods:
The present study was a double-blind randomized controlled clinical trial in Yazd conducted during November 2009 until July 2010. The sample included 44 postmenopausal osteoporotic women who were randomly assigned into two groups: the garlic group (GG) and the placebo group (PG). Participants in GG took two garlic tablets daily for 1 month and the participants in PG took placebo tablets in the same manner. Serum interlukin-1, interlukin-6, and tumor necrosis factor alpha (TNF-α) were measured using the ELISA method before and after the intervention. Also, 24-hour dietary recall was recorded for estimation of daily intake of some nutrients. Data were analyzed using SPSS software.

Results:
There was no statistically significant difference between interlukin-1 and interlukin-6 in the two groups before and after the intervention. The mean of TNF-α did not show any statistically significant difference between the two groups before and after the intervention, but it was significantly reduced by about 47% (from 31.14±50.53 to 19.33±22.19 ng/ml, P-value = 0.05) in GG after the intervention, However, no significant difference was seen in PG.

Conclusions:
The present study produced some evidence for an immunomodulatory effect of garlic, as well as the modulation of cytokine production.

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