The Shear Stress of Busting Blood Clots

ArticleinNew England Journal of Medicine 367(14):1361-3 · October 2012with30 Reads
Impact Factor: 55.87 · DOI: 10.1056/NEJMcibr1207994 · Source: PubMed


    Systemic delivery of tissue-type plasminogen activator (t-PA) to dissolve a thrombus after a heart attack or stroke is accompanied by the risk of hemorrhage. A recent study shows the use of nanoaggregates to target t-PA to the thrombus in mouse models of mesenteric injury and pulmonary embolism.