Febrile ulceronecrotic Mucha-Habermann disease: A case report and review of the literature
First Dermatologic Clinic, Aristotle University of Thessaloniki, Greece. Acta Dermato Venereologica
(Impact Factor: 3.03).
02/2008; 88(4):350-5. DOI: 10.2340/00015555-0441
Febrile ulceronecrotic Mucha-Habermann disease is a severe variant of pityriasis lichenoides et varioliformis acuta characterized by the sudden onset of ulceronecrotic skin lesions and associated with high fever and systemic symptoms. We report here a case of a 20-year-old woman in whom the disease started as pityriasis lichenoides et varioliformis acuta and evolved to febrile ulceronecrotic Mucha-Habermann disease. Almost 90% of the body surface was involved, together with high fever and malaise. Steroids alone proved to be an insufficient therapeutic procedure. The remission achieved was attributed to the use of methotrexate. To our knowledge, only 39 cases of febrile ulceronecrotic Mucha-Habermann disease have been reported in the literature to date.
Available from: Constança Margarida Sampaio Cruz
- "No recurrence has been shown with high doses of corticosteroids and antibiotics in the first weeks (complete resolution of the lesions) and maintenance treatment for over 2–6 months with half doses of antibiotics . Because of the severity of disease in the present study and in an effort to avoid recurrences, the patient was treated with tetracycline at a dose of 2 g/day until the end of the first month and 1 g/day for 2 more months. "
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ABSTRACT: A male dark-skinned patient, 33 years old, complaining of a 1-month history of skin lesions in the abdominal region and high fever was admitted to the clinical ward. There were ulcerated and coalescent skin lesions all over the body but sparing the palmar region. The culture of material obtained from the penile lesions was positive for . He was treated with oxacillin and prednisone. The patient persisted with high fever and skin lesions. After histopathological diagnosis of Mucha Habermann's disease, treatment was started with tetracycline with rapid improvement of the lesions. He was reexamined by the dermatologic service with no recurrences during the 12 months of follow-up. At this time, there was a great number of keloid scars from the skin lesions.
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