Article

Inkjet-Printed Microfluidic Multianalyte Chemical Sensing Paper

Department of Applied Chemistry, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
Analytical Chemistry (Impact Factor: 5.64). 09/2008; 80(18):6928-34. DOI: 10.1021/ac800604v
Source: PubMed

ABSTRACT

This paper presents an inkjet printing method for the fabrication of entire microfluidic multianalyte chemical sensing devices made from paper suitable for quantitative analysis, requiring only a single printing apparatus. An inkjet printing device is used for the fabrication of three-dimensional hydrophilic microfluidic patterns (550-mum-wide flow channels) and sensing areas (1.5 mm x 1.5 mm squares) on filter paper, by inkjet etching, and thereby locally dissolving a hydrophobic poly(styrene) layer obtained by soaking of the filter paper in a 1 wt % solution of poly(styrene) in toluene. In a second step, the same inkjet printing device is used to print "chemical sensing inks", comprising the necessary reagents for colorimetric analytical assays, into well-defined areas of the patterned microfluidic paper devices. The arrangement of the patterns, printed inks, and sensing areas was optimized to obtain homogeneous color responses. The results are "all-inkjet-printed" chemical sensing devices for the simultaneous determination of pH, total protein, and glucose in clinically relevant concentration ranges for urine analysis (0.46-46 muM for human serum albumin, 2.8-28.0 mM for glucose, and pH 5-9). Quantitative data are obtained by digital color analysis in the L*a*b* color space by means of a color scanner and a simple computer program.

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    • "However, such an approach is extremely time-consuming for large-scale detection processes. To address this problem, several recent studies have demonstrated the use of inkjet printing technology in depositing biomaterials or functional materials in carefully defined regions of the paper surface252627. Inkjet printing has many advantages for PAD manufacturing, including a rapid throughput, low cost, a straightforward process, good versatility, and the potential for mass production. "

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    • "Wax printing has become a popular way to produce paper-based microfluidics with a number of variations used to define microfluidic patterns (Carrilho et al. 2009; Lu et al. 2009). Direct inkjet printing of wax-based materials has been applied to produce complex patterns in paper (Li et al. 2010), and as well as direct printing of hydrophobic barriers , inkjet printing methods have also been used to " etch " pre-treated hydrophobic paper to restore hydrophilic channels where desired (Abe et al. 2008, 2010). Most paper-based microfluidic devices rely on optical methods of detection such as colorimetric or fluorescent detection. "
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    ABSTRACT: Paper-based microfluidics combined with printed electronics has the potential to yield exceptionally powerful point-of-care diagnostic devices at extremely low cost. To achieve such devices, new manufacturing methodologies must be developed to allow scalable, low-cost production whilst maintaining good reproducibility and performance. In this paper, we discuss the use of high-resolution inkjet printing of various advanced materials as a means to achieve the production of such devices. We present preliminary examples of printing techniques to produce both paper-based microfluidic devices and printed electronic components, which could be further developed into highly integrated, powerful, yet single-use, diagnostic devices. High-resolution inkjet printing of PDMS hydrophobic barriers on nitrocellulose membranes is demonstrated as a means to generate precise (~60-μm-wide) microfluidic circuits allowing low sample volume consumption. To our knowledge, these are the narrowest features produced in paper-based analytical devices via non-lithographic methods. In addition, a novel printing technique based upon agarose gel is demonstrated as a means to directly print microfluidic circuits in paper that may reduce fabrication time and costs as well allow deposition of agarose gel for electrophoresis applications. Printing methods are also used to deposit silver nanoparticle ink electrodes on nitrocellulose with good conductivity, and an all-printed, organic field-effect transistor on a silicon substrate is further presented. These examples serve to highlight the potential application of advanced printing techniques to the production of low-cost, highly functional diagnostic devices.
    Full-text · Article · Aug 2015 · Microfluidics and Nanofluidics
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    • "In addition, inkjet-printed electronics can be easily bonded with microÀuidic channels using appropriate inkjet printable materials such as SU-8. Inkjet-printed microÀuidic papers have been introduced for chemical sensing and diagnosing applications [4], [5]. Chemical or biochemical sensors have been realized by using capacitive electrodes. "
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    ABSTRACT: In this letter, a novel fluid-reconfigurable advanced and delayed phase line using a microfluidic composite right/left-handed (CRLH) transmission line (TL) is proposed. A CRLH-TL prototype is inkjet-printed on a photo-paper substrate. In addition, a laser-etched microfluidic channel in poly(methyl methacrylate) (PMMA) is integrated with the CRLH TL using inkjet-printed SU-8 as a bonding material. The proposed TL provides excellent phase-tuning capability that is dependent on the fluidic materials used. As the fluid is changed, the proposed TL can have negative-, zero-, and positive-phase characteristics at 900 MHz for different fluids. The performance of the TL is successfully validated using simulation and measurement results.
    Full-text · Article · Feb 2015 · IEEE Microwave and Wireless Components Letters
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