Association Between Maternal Diabetes in Utero and Age at Offspring's Diagnosis of Type 2 Diabetes

Sansum Diabetes Research Institute, Santa Barbara, California, USA.
Diabetes care (Impact Factor: 8.42). 08/2008; 31(11):2126-30. DOI: 10.2337/dc08-0769
Source: PubMed


The purpose of this study was to examine age of diabetes diagnosis in youth who have a parent with diabetes by diabetes type and whether the parent's diabetes was diagnosed before or after the youth's birth.
The cohort comprised SEARCH for Diabetes in Youth Study participants (diabetes diagnosis 2001-2005) with a diabetic parent. SEARCH is a multicenter survey of youth with diabetes diagnosed before age 20 years.
Youth with type 2 diabetes were more likely to have a parent with either type 1 or type 2 diabetes (mother 39.3%; father 21.2%) than youth with type 1 diabetes (5.3 and 6.7%, respectively, P < 0.001 for each). Type 2 diabetes was diagnosed 1.68 years earlier among those exposed to diabetes in utero (n = 174) than among those whose mothers' diabetes was diagnosed later (P = 0.018, controlled for maternal diagnosis age, paternal diabetes, sex, and race/ethnicity). Age at diagnosis of type 1 diabetes for 269 youth with and without in utero exposure did not differ significantly (difference 0.96 year, P = 0.403 after adjustment). Controlled for the father's age of diagnosis, father's diabetes before the child's birth was not associated with age at diagnosis (P = 0.078 for type 1 diabetes; P = 0.140 for type 2 diabetes).
Type 2 diabetes was diagnosed at younger ages among those exposed to hyperglycemia in utero. Among youth with type 1 diabetes, the effect of the intrauterine exposure was not significant when controlled for mother's age of diagnosis. This study helps explain why other studies have found higher age-specific rates of type 2 diabetes among offspring of women with diabetes.

Download full-text


Available from: Dana Dabelea
  • Source
    • "Preexisting T2DM in pregnancy has lifetime effects on the offspring including higher rates of obesity, higher rates of glucose intolerance, higher rates of T2DM, and earlier age of T2DM onset [29–32]. It is possible that this recent increase in childhood T2DM is occurring because women are developing T2DM progressively earlier, resulting in the most recent generations being the first exposed to an intrauterine environment of hyperglycemia and insulin resistance at the early stages of pregnancy. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Type 2 diabetes mellitus (T2DM) is classically viewed as a disease of adults caused by poor nutrition, physical inactivity, and obesity. However, with increasing awareness of the heterogeneity of T2DM, new risk factors are being identified that add complexity. Some of these new risk factors have been identified in Canadian people with Aboriginal Oji-Cree heritage, a group that demonstrates one of the highest rates of T2DM in the world. This high prevalence may be due to the rapid change, over the past 50 years, away from their traditional way of life on the land. Another environmental change is the increased rate of pregnancies complicated by obesity, gestational diabetes, or T2DM, resulting in more children being exposed to an abnormal intrauterine environment. Furthermore, the Oji-Cree of central Canada possesses the unique HNF-1α G319S polymorphism associated with reduced insulin secretion. We propose that intrauterine exposure to maternal obesity and T2DM, associated with the HNF-1α G319S polymorphism, results in fetal programming that accelerates the progression of early-onset T2DM. This paper describes the evolution of T2DM in children with a focus on the Oji-Cree people over the past 25 years and the unique prenatal and postnatal gene-environment interaction causing early-onset T2DM.
    Full-text · Article · Jan 2012 · Journal of nutrition and metabolism
  • Source

    Full-text · Article ·
  • [Show abstract] [Hide abstract]
    ABSTRACT: In this paper, simulation results of the gate misalignment effects on the sub-threshold characteristics of asymmetric (ADG) and symmetric (SDG) double-gate MOSFET (DG-MOSFET) in the sub-100 nm regime are presented. Gates alignment in DG-MOSFETs becomes more and more difficult as devices are scaling down in non-self-aligned double-gate processes. The results show that gate misalignment effects are not as serious as generally expected and 60-80% misalignment is considered to be tolerable in some circuit applications.
    No preview · Conference Paper · Feb 2002
Show more