Article

Mindfulness meditation effects on CD4 + T lymphocytes in HIV-1 infected adults: a small, randomized controlled trial. Brain Behavior and Immunity, 23, 184-188

Department of Psychiatry and Biobehavioral Sciences, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, 300 Medical Plaza, Suite 3109, Los Angeles, CA 90095, USA.
Brain Behavior and Immunity (Impact Factor: 5.89). 08/2008; 23(2):184-8. DOI: 10.1016/j.bbi.2008.07.004
Source: PubMed

ABSTRACT

Mindfulness meditation training has stress reduction benefits in various patient populations, but its effects on biological markers of HIV-1 progression are unknown. The present study tested the efficacy of an 8-week Mindfulness-based stress reduction (MBSR) meditation program compared to a 1-day control seminar on CD4+ T lymphocyte counts in stressed HIV infected adults. A single-blind randomized controlled trial was conducted with enrollment and follow-up occurring between November 2005 and December 2007. A diverse community sample of 48 HIV-1 infected adults was randomized and entered treatment in either an 8-week MBSR or a 1-day control stress reduction education seminar. The primary outcome was circulating counts of CD4+ T lymphocytes. Participants in the 1-day control seminar showed declines in CD4+ T lymphocyte counts whereas counts among participants in the 8-week MBSR program were unchanged from baseline to post-intervention (time x treatment condition interaction, p=.02). This effect was independent of antiretroviral (ARV) medication use. Additional analyses indicated that treatment adherence to the mindfulness meditation program, as measured by class attendance, mediated the effects of mindfulness meditation training on buffering CD4+ T lymphocyte declines. These findings provide an initial indication that mindfulness meditation training can buffer CD4+ T lymphocyte declines in HIV-1 infected adults. Clinical Trials Registration: clinicaltrials.gov, Identifier: NCT00600561.

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    • "A PubMed search of the term mindfulness revealed the following trend: 11 articles published between 1980 and 1989; 28 articles published between 1990 and 1999; 510 articles published between 2000 and 2010; and 2,263 articles published between 2011 and August 2015. Mindfulness meditation has been studied in a broad range of mental and physical health outcomes, such as major depression [4], cancer [5], HIV pathogenesis [6], multiple sclerosis [7], chronic low back pain [8], chronic insomnia [9], and chronic kidney disease [10]. "
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    • "A mounting body of literature points to the positive benefits of mindfulness based interventions in the promotion of subjective and objective measures of physical health (Baer, 2003; Brown et al., 2007; Epel et al., 2009). Training in mindfulness based interventions has been associated with increased antibody titer response to influenza vaccination (Davidson et al., 2003), buffering of CD4+ lymphocyte declines in HIV-1 infected individuals (Creswell et al., 2009), reduced interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-a) levels in response to an acute stressor (Pace et al., 2009, 2010) and blood pressure (BP) reductions in individuals with hypertension (Paul-Labrador et al., 2006; Schneider et al., 2005). Despite research linking mindfulness training to changes in physiological variables, the mechanisms driving the relationship remain unclear. "
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    • "An alternate to CBSM which has garnered increasing attention as a plausible HIV intervention is Mindfulness Based Stress Reduction (MBSR). In addition to positive changes in mindfulness, several studies have reported increases in psychoimmune function and decrease in HIV symptomology following an eight week intervention (Creswell et al., 2009; Duncan et al., 2012; Gayner et al., 2012; SeyedAlinaghi et al., 2012). Hence, interventions focusing on cognitive regulation of emotional appraisals may be a plausible option for restoration of neurocognitive, behavioral and immune function for individuals demonstrating poor assimilation of feelings and emotions (Davidson et al., 2003; Hölzel et al., 2011; Paul et al., 2013). "
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