Bendigoles A~C, New Steroids from Gordonia australis Acta 2299†

Institut für Chemie, Technische Universität Berlin, Germany.
The Journal of Antibiotics (Impact Factor: 1.73). 07/2008; 61(6):356-64. DOI: 10.1038/ja.2008.50
Source: PubMed


Bendigoles A approximately C are the first secondary metabolites to be isolated from a member of the actinomycete genus Gordonia. They were detected in a culture filtrate extract of Gordonia australis Acta 2299 by HPLC-diode array analysis and characterized as new steroids by mass spectrometry and NMR experiments. Bendigole C show binding affinity to the human progesterone and A approximately C to androgen receptor but are inactive at mineralocorticoid and estrogen receptors. In in vitro transactivation studies bendigoles A and C showed moderate and weak androgenic activities.

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Available from: Hans-Peter Fiedler, May 24, 2015
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    • "Bendigoles are the first secondary metabolites to be isolated from a member of the actinomycete genus Gordonia and were detected in the culture filtrate extract of G. australis. One of these steroid compounds, Bendigole C, showed binding affinity to the human progesterone and Bendigoles A-C to the androgen receptor, but are inactive at mineralocorticoid and estrogen receptors (Schneider et al., 2008). "
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