NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but maintained in HIV controllers

1INSERM, U1012, Le Kremlin Bicêtre, France 2Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France 3INSERM U986, Hôpital St-Vincent de Paul, Paris, France 4Université Paris-Sud, U1012, Le Kremlin Bicêtre, France 5AP-HP, Service de Médecine Interne et Maladies Infectieuses, Hôpital Bicêtre, Le Kremlin Bicêtre, France.
JAIDS Journal of Acquired Immune Deficiency Syndromes (Impact Factor: 4.56). 09/2012; 62(1). DOI: 10.1097/QAI.0b013e318274579f
Source: PubMed


NKG2D mediates an important co-stimulatory pathway in CD8 T cells. In HIV infection, we found that NKG2D expression on both total and HIV-specific CD8 T cells was significantly lower in viremic patients than in HIV controllers. Antiretroviral therapy partially restored NKG2D expression on HIV-specific CD8 T cells. We observed a negative correlation between the respective expression levels of CD38 and NKG2D on total CD8 and HIV-specific CD8 T cells. The maintenance of NKG2D expression on CD8 T cells in HIV controllers may contribute to better cell function.

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