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[Combination of compound Xuanju capsule and tamoxifen citrate for idiopathic oligozoospermia]
Abstract
To evaluate the clinical effects of Compound Xuanju Capsule combined with tamoxifen citrate on the seminal parameters of men with idiopathic oligozoospermia.
We equally assigned 120 men with idiopathic oligozoospermia to receive Compound Xuanju Capsule plus tamoxifen citrate (experiment group) or tamoxifen citrate alone (control group). After 3 months of medication, we compared the concentration and total number of sperm with the baseline, and analyzed the influence of the duration of natural infertility on the therapeutic effect.
Both the concentration and total number of sperm were significantly increased in both the experiment and the control groups after 3 months of medication as compared with the baseline (P < 0.05), and the increases were even more significant in the former than in the latter group (P < 0.05). The therapeutic efficacy was remarkably better in the patients with natural infertility < or = years than in those > 3 years (P < 0.05).
Compound Xuanju Capsule combined with tamoxifen citrate produces satisfactory results in the treatment of idiopathic oligozoospemia, and therefore can be used as a first-line therapy for this disease.
... Modern medical research has found that Black Ants, Epimedium and other drugs are rich in amino acids, vitamins, coenzymes, flavonoids and other ingredients,which can significantly increase the content of various nutrients in the human body. [17] Clinical studies have shown that compound Xuanju capsule can effectively improve semen quality and reduce sperm chromatin damage in infertile men with oligoasthenotspermia; [18] increase the level of sex hormone, promote semen secretion, improve the function of sexual organs; [19] significantly increase the concentration and total number of sperm, increase sperm motility; [20] effectively improve the semen quality and sperm morphology of infertile male smokers; reduce genital inflammation and regulate sexual dysfunction. [21] However, the intervention of Chinese patent medicine lacks the process of syndrome differentiation and treatment in traditional Chinese medicine, it is difficult to give full play to the best effect of traditional Chinese medicine treatment. ...
Background:
Oligoasthenotspermia is a condition in which the number and motility of sperm in the semen of fertile men are lower than the normal level. Oligoasthenotspermia not only causes damage to the reproductive system, but also causes infertility in severe cases. Compound Xuanju capsule is a kind of Chinese patent medicine. Traditional medicine believes that compound Xuanju capsule can nourish kidney Yang, benefit kidney essence, improve semen quality, and treat infertility caused by oligoasthenotspermia. Clinical practice shows that compound Xuanju capsule combined with western medicine has a good therapeutic effect on male oligoasthenotspermia, but there is no evidence of evidence-based medicine. The purpose of this study is to systematically evaluate the efficacy and safety of compound Xuanju capsule combined with western medicine in the treatment of male oligoasthenotspermia, and to improve the evidence-based basis for the clinical application of compound Xuanju capsule in the treatment of male oligoasthenotspermia.
Methods:
A systematic search was performed by retrieving on English database (PubMed, Embase, Web of Science, and The Cochrane Library) and Chinese database (CNKI, Wanfang, Weipu (VIP), CBM). Besides, manually search for Google and Baidu academic of compound XuanJu capsule combined western medicine in the treatment of male oligoasthenotspermia in randomized controlled clinical research. The retrieval time limit was from the establishment of the database to July 2020. Two researchers independently extracted and evaluated the quality of the data in the included study. A meta-analysis was performed using RevMan5.3 software, no language restrictions.
Results:
In this study, the efficacy and safety of compound Xuanju capsule combined with western medicine in the treatment of male oligoasthenotspermia were evaluated by the total effective rate, semen parameters and other indexes.
Conclusions:
This study will provide reliable evidence-based evidence for the clinical application of compound Xuanju capsule combined with western medicine in the treatment of male oligoasthenotspermia.
Ethics and dissemination:
Private information from individuals will not be published. This systematic review also does not involve endangering participant rights. Ethical approval was not required. The results may be published in a peer-reviewed journal or disseminated at relevant conferences.OSF Registration number: DOI 10.17605/OSF.IO/2PM8T.
... Tissue antibody staining was not significantly different between groups. Tamoxifen, used for treatment of breast cancer is also used for oligozoospermia in andrology [16]. Another effect of tamoxifen used in the treatment is anti-fibrogenic effect in keloids [7], rhinophyma [17], and riedel thyroiditis treatment [18]. ...
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