Computational analysis of noncoding RNAs

Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
WIREs RNA (Impact Factor: 6.02). 11/2012; 3(6):759-78. DOI: 10.1002/wrna.1134
Source: PubMed


Noncoding RNAs have emerged as important key players in the cell. Understanding their surprisingly diverse range of functions is challenging for experimental and computational biology. Here, we review computational methods to analyze noncoding RNAs. The topics covered include basic and advanced techniques to predict RNA structures, annotation of noncoding RNAs in genomic data, mining RNA-seq data for novel transcripts and prediction of transcript structures, computational aspects of microRNAs, and database resources. These authors contributed equally WIREs RNA 2012. doi: 10.1002/wrna.1134
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