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[Show abstract][Hide abstract] ABSTRACT: Ultrastructual studies of experimentally infected chicken (n=5) ileum reveal that virulent Salmonella (3,10:r:-) signal their own phagocytosis by tissue macrophages, and are able to dodge host defence mechanisms. The observed fusion of membrane vesicles (MVs) liberated from virulent organisms with closely interacting macrophages is proposed here to constitute a mechanism of type III secretion-like system of gram-negative organisms in general, in order to translocate the necessary biochemical signals into the cytosol of macrophages (eukaryotic host cells). This leads to (1) membrane ruffling culminating in augmented phagocytosis of salmonellae, (2) inhibition of phagosome-lysosome (P-L) fusion for survival and replication of pathogens within the host cytoplasm and (3) initiation of apoptosis of the infected macrophages and ultimate release of replicated salmonellae from the migrating host cells.
Full-text · Article · Jan 2000 · The Journal of Poultry Science