Bone Flap Resorption: Risk Factors for the Development of a Long-Term Complication following Cranioplasty after Decompressive Craniectomy

Johann Wolfgang Goethe-University Frankfurt am Main, Department of Neurosurgery, Schleusenweg 2-16, Frankfurt am Main, Hessen, Germany, 60528
Journal of neurotrauma (Impact Factor: 3.71). 09/2012; 30(2). DOI: 10.1089/neu.2012.2542
Source: PubMed


Aseptic bone flap resorption (BFR) is a known long-term complication after cranioplasty (CP). We analyzed our institutional data in order to identify risk factors for BFR. From October 1999 to April 2012, 254 patients underwent CP after decompressive craniectomy (DC) at our institution and had a long-term follow-up period of more than 1 year after CP (range 12-146 months). Overall, BFR occurred in 10 of 254 patients as long-term complication after CP (4%). BFR developed more often in patients aged ≤ 18 years (p=0.008), in patients who previously underwent DC due to traumatic brain injury (p=0.04), and in patients with multiple fractures within the reinserted bone flap (p=0.002). Furthermore, BFR developed significantly more often in patients who underwent cranioplasty ≤ 2 months after DC (p=0.008), as well as in patients with wound healing disturbance or abscess as an early complication after the CP procedure (p=0.01). The multivariate analysis of the present data identified the presence of multiple fractures within the bone flap (p=0.002, OR 10.3, 95% CI 2.4-43.8), wound infection after CP (p=0.003, OR 12.3, 95% CI 2.3-65.3), and cranioplasty performed ≤ 2 months after DC (p=0.01, OR 6.3, 95% CI 1.5-26.3) as independent risk factors for the development of BFR after CP in a large series with long term follow-up. This might influence future surgical decision making, especially in patients fulfilling high risk criteria for developing BFR.

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    • "Decompressive hemicraniectomy represents a life saving treatment for malignant intracranial hypertension caused by multiple pathologies, as hemispheric cerebral infarction, nontraumatic intraparenchymal hemorrhage, aneurysmal subarachnoid hemorrhage, and venous sinus thrombosis[1][4]. This surgical procedure includes several complications like infections, wound dehiscence and post-operative CSF leak, epidural hemorrhage[5], bone resorption[6], and epilepsy[7]; moreover, communicating hydrocephalus and ex-vacuo ventricular dilata- tions[8], which often require permanent ventricular CSF shunt after bone flap replacement[9], can occur. Many authors have debated about the physiopathology of hydrocephalus after ischemic infarction[10]and about the timing of cranioplasty to prevent this complication[11]. "

    Preview · Article · Jan 2016 · Open Access Library Journal
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    • "One might suspect that a longer follow-up period in the present study could have revealed bone resorption in more patients. However, Schuss et al. found in their study that 60 % of bone flap resorption occurred within 1 year of follow-up and that no resorption was observed among patients followed for more than 5 years [45]. On the other hand, in a study by Grant et al. on patients younger than 19 years, bone resorption occurred in 20 out of 40 patients. "
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    ABSTRACT: Renewed interest has developed in decompressive craniectomy, and improved survival is shown when this treatment is used after malignant middle cerebral artery infarction. The aim of this study was to investigate the frequency and possible risk factors for developing surgical site infection (SSI) after delayed cranioplasty using autologous, cryopreserved bone. This retrospective study included 74 consecutive patients treated with decompressive craniectomy during the time period May 1998 to October 2010 for various non-traumatic conditions causing increased intracranial pressure due to brain swelling. Complications were registered and patient data was analyzed in a search for predictive factors. Fifty out of the 74 patients (67.6 %) survived and underwent delayed cranioplasty. Of these, 47 were eligible for analysis. Six patients (12.8 %) developed SSI following the replacement of autologous cryopreserved bone, whereas bone resorption occurred in two patients (4.3 %). No factors predicted a statistically significant rate of SSI, however, prolonged procedural time and cardiovascular comorbidity tended to increase the risk of SSI. SSI and bone flap resorption are the most frequent complications associated with the reimplantation of autologous cryopreserved bone after decompressive craniectomy. Prolonged procedural time and cardiovascular comorbidity tend to increase the risk of SSI.
    Full-text · Article · Feb 2014 · Acta Neurochirurgica
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    ABSTRACT: Decompressive craniectomy (DC) due to intractably elevated intracranial pressure mandates later cranioplasty (CP). However, the optimal timing of CP remains controversial. We therefore analyzed our prospectively conducted database concerning the timing of CP and associated post-operative complications. From October 1999 to August 2011, 280 cranioplasty procedures were performed at the authors' institution. Patients were stratified into two groups according to the time from DC to cranioplasty (early, ≤2 months, and late, >2 months). Patient characteristics, timing of CP, and CP-related complications were analyzed. Overall CP was performed early in 19% and late in 81%. The overall complication rate was 16.4%. Complications after CP included epidural or subdural hematoma (6%), wound healing disturbance (5.7%), abscess (1.4%), hygroma (1.1%), cerebrospinal fluid fistula (1.1%), and other (1.1%). Patients who underwent early CP suffered significantly more often from complications compared to patients who underwent late CP (25.9% versus 14.2%; p=0.04). Patients with ventriculoperitoneal (VP) shunt had a significantly higher rate of complications after CP compared to patients without VP shunt (p=0.007). On multivariate analysis, early CP, the presence of a VP shunt, and intracerebral hemorrhage as underlying pathology for DC, were significant predictors of post-operative complications after CP. We provide detailed data on surgical timing and complications for cranioplasty after DC. The present data suggest that patients who undergo late CP might benefit from a lower complication rate. This might influence future surgical decision making regarding optimal timing of cranioplasty.
    No preview · Article · Dec 2011 · Journal of neurotrauma
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