Near-Infrared Emitting Radioactive Gold Nanoparticles with Molecular Pharmacokinetics

Department of Chemistry, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080 (USA)∼jiezheng.
Angewandte Chemie International Edition (Impact Factor: 11.26). 10/2012; 51(40):10118-22. DOI: 10.1002/anie.201203031
Source: PubMed


A molecular nanoprobe: Glutathione-coated near-infrared-emitting radioactive gold nanoparticles have been synthezised and behave like small-molecule contrast agents in pharmocokinetics. These nanoparticles show a rapid distribution half-life, a desirable elimination half-life, and hold promise for single-photon emission computed tomography (SPECT) and fluorescence imaging.

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