Interactive Decomposition and Mapping of Saccular Cerebral Aneurysms Using Harmonic Functions: Its First Application With "Patient-Specific" Computational Fluid Dynamics (CFD) Simulations
IEEE transactions on medical imaging 08/2012; 32(2). DOI: 10.1109/TMI.2012.2216542
Recent developments in medical imaging and advanced computer modeling simulations) now enable studies designed to correlate either simulated or measured 'patient-specific' parameters with the natural history of intracranial aneurysm i.e., ruptured or unruptured. To achieve significance, however, these studies require rigorous comparison of large amounts of data from large numbers of aneurysms, many of which are quite dissimilar anatomically. In this study, we present a method that can likely facilitate such studies as its application could potentially simplify an objective comparison of surface-based parameters of interest such as wall shear stress and blood pressure using large multi-patient, multi-institutional data sets.
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ABSTRACT: Gold nanorods (GNRs) can be used in various biomedical applications; however, very little is known about their in vivo tissue distribution by radiolabeling. Here, we have developed a rapid and simple method with high yield and without disturbing their optical properties for radiolabeling of gold rods with iodine-131 in order to track in vivo tissue uptake of GNRs after systemic administration by biodistribution analysis and γ-imaging. Following intravenous injection into rat, PEGylated GNRs have much longer blood circulation times.
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