Modes of action of Leishmanicidal antimicrobial peptides

Immunity & Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.
Future Microbiology (Impact Factor: 4.28). 09/2012; 7(9):1047-59. DOI: 10.2217/fmb.12.85
Source: PubMed


Leishmaniasis is one of the major neglected tropical diseases of the world. It is present in 88 countries with an estimated number of 500,000 cases of visceral leishmaniasis and 1.5 million cases of cutaneous disease. No effective vaccinations are available against leishmaniasis and the efficacy of existing treatments is compromised due to the emergence of drug resistance. Thus, there is an urgent need to develop new compounds with antileishmanial activity. Antimicrobial peptides have potential as novel antileishmanial therapy, either for use alone or in combination with current drug regimens. The modes of action of these peptides against Leishmania includes: membrane disruption leading to necrotic cell death; induction of apoptosis; binding to intracellular target(s); and indirect effects via immunomodulation of host immune cells. This article reviews the mechanisms of action of antimicrobial peptides with leishmanicidal activity.

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Available from: Bradford S McGwire, Apr 15, 2015
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    • "Os metabólitos casearinas isolados de C. sylvestris têm demonstrado uma boa ação contra Trypanosoma cruzi e Leishmania spp (Bou et al., 2014), provavelmente por provocarem o rompimento da membrana plasmática do parasito. Isso ocasiona esgotamento dos gradientes iônicos, efluxo de nutrientes e outros componentes citoplasmáticos, provocando a lise osmótica e, consequentemente, a morte celular (Marr et al., 2012). Das espécies estudadas contra L. amazonensis, os extrados com melhor ação foram o hexânico e o metanólico das folhas da espécie L. pubescens, com IC 50 de 3,5μg/mL e 3,9μg/mL respectivamente. "

    Full-text · Article · Dec 2015
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    • "r , final results of both experimental studies have not yet been published . Another important protozoal infection is leishmaniasis , which is one of the main neglected tropical infections of the world with occurrence in 88 countries and an estimated num - ber of 500 , 000 cases of visceral form and 1 . 5 million cases of cutaneous leishmaniasis ( Marr et al . 2012 ) . Drug resistance compromises present treatment options and absence of effec - tive vaccination warrants to search for new compounds with anti - leishmanial activity . Nanotechnology is implied in two different directions : the development of nano - liposomal for - mulations containing conventional anti - leishmanial drugs , for insta"
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