Preparation and characterization of antimicrobial wound dressings based on silver, gellan, PVA and borax

Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Carbohydrate polymers 10/2012; 90(3):1362-70. DOI: 10.1016/j.carbpol.2012.07.005
Source: PubMed


Silver-loaded dressings are designed to provide the same antimicrobial activity of topical silver, with the advantages of a sustained silver release and a reduced number of dressing changes. Moreover, such type of dressing must provide a moist environment, avoiding fiber shedding, dehydration and adherence to the wound site. Here we describe the preparation of a novel silver-loaded dressing based on a Gellan/Hyaff(®) (Ge-H) non woven, treated with a polyvinyl alcohol (PVA)/borax system capable to enhance the entrapment of silver in the dressing and to modulate its release. The new hydrophilic non woven dressings show enhanced water uptake capability and slow dehydration rates. A sustained silver release is also achieved. The antibacterial activity was confirmed on Staphylococcus aureus and Pseudomonas aeruginosa.

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    • "No haemolytic effect was observed. Cencetti et al., 2012 examined antimicrobial wound dressings designed for slow silver release. Nonwoven gellan-Hyaff 1 (benzyl derivative of hyaluronic acid) patches were used as a matrix. "
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    • "Sodium alginate, widely used in food and pharmaceutical industries, has been used in a number of wound treatments, for both acute or chronic wounds, because when it comes into contact with the exudate or blood it forms a protective fibrous gel, which is hydrophilic, hemostatic, and rich in calcium [22]. Polyvinyl alcohol was used as film forming agent and has been often used in combination with other polymers for wound healing applications [23] [24] "
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