Exploring converse molecular mechanisms of anti-HIV-1 antibodies using a synthetic CXCR4 mimic

Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, 91052 Erlangen, Germany.
Bioorganic & medicinal chemistry letters (Impact Factor: 2.42). 08/2012; 22(19):6099-102. DOI: 10.1016/j.bmcl.2012.08.035
Source: PubMed


Different molecular mechanisms of the two broadly neutralizing anti-HIV-1 antibodies b12 and VRC01, as evidenced by their converse effects on the interaction of HIV-1 envelope glycoprotein gp120 with cellular coreceptors, were demonstrated using a synthetic CXCR4 mimetic peptide (CX4-M1) as coreceptor surrogate. While the interaction of gp120 with CX4-M1 was distinctly enhanced by VRC01, b12 was shown to have the contrary effect, and also to inhibit the VRC01-induced enhancement of gp120 binding to the CXCR4 mimetic peptide.

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