Reduction of menstrual blood loss by prostaglandin inhibitors

Nuffield Department of Obstetrics and Gynœcology, John Radcliffe Hospital, University of Oxford, Headington, Oxford, United Kingdom
The Lancet (Impact Factor: 45.22). 05/1976; 1(7963):774-6. DOI: 10.1016/S0140-6736(76)91612-3
Source: PubMed


Six patients with menorrhagia due to dysfunctional uterine bleeding and one patient with an intrauterine contraceptive device were treated with prostaglandin-synthetase inhibitors in an attempt to reduce their excessive menstrual blood-loss. Mefenamic acid (six patients) or flufenamic acid (one patient) taken during menstruation for 2-3 cycles reduced menstrual loss in each patient. These preliminary observations suggest a new treatment for a common gynaecological problem and could imply that prostaglandins are involved in the aetiology of excessive menstrual blood-loss in such patients.

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