Reduction of menstrual blood loss by prostaglandin inhibitors
Nuffield Department of Obstetrics and Gynœcology, John Radcliffe Hospital, University of Oxford, Headington, Oxford, United KingdomThe Lancet (Impact Factor: 45.22). 05/1976; 1(7963):774-6. DOI: 10.1016/S0140-6736(76)91612-3
Six patients with menorrhagia due to dysfunctional uterine bleeding and one patient with an intrauterine contraceptive device were treated with prostaglandin-synthetase inhibitors in an attempt to reduce their excessive menstrual blood-loss. Mefenamic acid (six patients) or flufenamic acid (one patient) taken during menstruation for 2-3 cycles reduced menstrual loss in each patient. These preliminary observations suggest a new treatment for a common gynaecological problem and could imply that prostaglandins are involved in the aetiology of excessive menstrual blood-loss in such patients.
Article: Dysfunctional uterine bleeding
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ABSTRACT: A successful pregnancy following bilateral uterine artery ligation performed in an attempt to relieve dysfunctional menorrhagia is reported. Serial biparietal diameters showed a normal growth curve and the newborn infant weighed 2640 g. The patient was normotensive throughtout the pregnancy. Prior to uterine artery ligation, she had had four pregnancies but there were no surviving children. It is suggested that uterine artery ligation may have a limited place in the management of patients with dysfunctional menorrhagia.
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