Effect of Vaginal Lubricants on Natural Fertility Reply

University of North Carolina at Chapel Hill, North Carolina, United States
Obstetrics and Gynecology (Impact Factor: 5.18). 07/2012; 120(1):44-51. DOI: 10.1097/AOG.0b013e31825b87ae
Source: PubMed


Over-the-counter vaginal lubricants have been shown to negatively affect in vitro sperm motility. The objective of this study was to estimate the effect of vaginal lubricant use during procreative intercourse on natural fertility.
Women aged 30-44 years with no history of infertility who had been trying to conceive for less than 3 months completed a baseline questionnaire on vaginal lubricant use. Subsequently, women kept a diary to record menstrual bleeding, intercourse, and vaginal lubricant use and conducted standardized pregnancy testing for up to 6 months. Diary data were used to determine the fertile window and delineate lubricant use during the fertile window. A proportional hazards model was used to estimate fecundability ratios with any lubricant use in the fertile window considered as a time-varying exposure.
Of the 296 participants, 75 (25%) stated in their baseline questionnaire that they use vaginal lubricants while attempting to conceive. Based on daily diary data, 57% of women never used a lubricant, 29% occasionally used a lubricant, and 14% used a lubricant frequently. Women who used lubricants during the fertile window had similar fecundability to those women who did not use lubricants (fecundability ratio 1.05, 95% confidence interval 0.59-1.85) after adjusting for age, partner race, and intercourse frequency in the fertile window.
Lubricants are commonly used by couples during procreative intercourse. Lubricant use during procreative intercourse does not appear to reduce the probability of conceiving.

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    ABSTRACT: OBJECTIVE: To assess the influence of an isotonic lubricant used during sperm sample collection on [1] ease of collection and [2] resultant sperm quality. DESIGN: Paired randomized cross-over design. SETTING: Tertiary hospital. DONOR(S): Healthy men over 18 years old with normal semen analysis as per World Health Organization 2010 guidelines. INTERVENTION(S): Collection of semen sample from 22 subjects by masturbation with or without the use of Pre-Seed personal lubricant. MAIN OUTCOME MEASURE(S): Qualitative survey results and quantitative sperm function outcomes were measured to determine resultant sperm quality and collection experience with and without Pre-Seed lubricant. RESULT(S): The qualitative questionnaire results showed that 73% of donors prefer the semen collection process with the isotonic lubricant and 55% recommended the use of lubricant in their everyday collection. The motility, viability, membrane integrity, levels of reactive oxygen species, total antioxidant capacity, and percentage of DNA damage in collected semen samples were not affected by the use of the lubricant. CONCLUSION(S): More donors prefer, and find it easier, to collect semen samples with the use of the lubricant. The isotonic lubricant Pre-Seed did not compromise sperm quality as evaluated in an array of sperm assays, suggesting its safe use in fertility patients as required during sperm collection.
    Full-text · Article · Feb 2013 · Fertility and sterility
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