Mitochondrial sirtuins: Regulators of protein acylation and metabolism

ArticleinTrends in Endocrinology and Metabolism 23(9):467-76 · August 2012with14 Reads
Impact Factor: 9.39 · DOI: 10.1016/j.tem.2012.07.004 · Source: PubMed
Abstract

Sirtuins are NAD(+)-dependent protein deacetylases and have been implicated in the regulation of metabolism, stress responses, and aging. Three sirtuins are located in mitochondria: SIRT3, 4, and 5. SIRT3 deacetylates and regulates the enzymatic activity of many metabolic enzymes in mitochondria, whereas SIRT5 removes two novel post-translational modifications, lysine malonylation and succinylation. Here, we review the current knowledge of how mitochondrial sirtuins function in metabolism and metabolic diseases, and offer a conceptual model how they may regulate mitochondrial function through distinct deacylation activities (deacetylation, demalonylation, or desuccinylation).