Genital Inflammation Predicts HIV-1 Shedding Independent of Plasma Viral Load and Systemic Inflammation

1Division of Human Biology and 2Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 USA 3Departments of Medicine 4Global Health 5Biostatistics, and 6Epidemiology, University of Washington, Seattle, WA 98195 USA 7Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya 8Coast General Hospital, Mombasa, Kenya.
JAIDS Journal of Acquired Immune Deficiency Syndromes (Impact Factor: 4.56). 08/2012; 61(4). DOI: 10.1097/QAI.0b013e31826c2edd
Source: PubMed


In women, genital HIV-1 RNA levels predict the risk of HIV-1 transmission independent of plasma viral load. To better understand the factors that contribute to genital HIV-1 shedding, we evaluated the relationships between genital and plasma cytokine concentrations and HIV-1 RNA levels. Vaginal, but not plasma, levels of interferon gamma-induced protein 10 (IP-10) were significantly associated with vaginal viral load, independent of plasma viral load. Thus, efforts to decrease HIV-1 transmission must take into account the role of local inflammation, which is not necessarily reflected in plasma measurements.

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