Delivery in female kidney transplant recipients with hepatitis C virus infection: Is it safe for mother and newborn?

ArticleinProgress in transplantation (Aliso Viejo, Calif.) 22(2):141-4, 154 · June 2012with4 Reads
Impact Factor: 0.84 · DOI: 10.7182/pit2012667 · Source: PubMed


    The aim of this report is to evaluate whether pregnancy is a risk factor for poor outcome of infection with hepatitis C virus or for allograft deterioration among kidney transplant recipients. The first case was in a 41-year-old pregnant kidney transplant recipient with hypercreatinemia and a history of toxic hepatitis. The second case was treated with interferon before transplant. Tacrolimus-based immunosuppressive regimens were used during the pregnancies. Hypertension complicated both pregnancies, and the pregnancies ended with cesarean delivery at preterm and term with healthy but low-weight newborns. The first patient became positive for hepatitis C virus RNA after pregnancy without a flare in transaminase level. Antibodies to hepatitis C virus were negative in the newborns. In conclusion, pregnancy should be promoted for kidney recipients infected with hepatitis C virus who have stable graft and liver function.