Intake of Fruits and Vegetables and Risk of Pancreatic Cancer in a Pooled Analysis of 14 Cohort Studies

University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
American journal of epidemiology (Impact Factor: 5.23). 08/2012; 176(5):373-86. DOI: 10.1093/aje/kws027
Source: PubMed


Fruit and vegetable intake may protect against pancreatic cancer, since fruits and vegetables are rich in potentially cancer-preventive nutrients. Most case-control studies have found inverse associations between fruit and vegetable intake and pancreatic cancer risk, although bias due to reporting error cannot be ruled out. In most prospective studies, inverse associations have been weaker and imprecise because of small numbers of cases. The authors examined fruit and vegetable intake in relation to pancreatic cancer risk in a pooled analysis of 14 prospective studies from North America, Europe, and Australia (study periods between 1980 and 2005). Relative risks and 2-sided 95% confidence intervals were estimated separately for the 14 studies using the Cox proportional hazards model and were then pooled using a random-effects model. Of 862,584 men and women followed for 7-20 years, 2,212 developed pancreatic cancer. The pooled multivariate relative risks of pancreatic cancer per 100-g/day increase in intake were 1.01 (95% confidence interval (CI): 0.99, 1.03) for total fruits and vegetables, 1.01 (95% CI: 0.99, 1.03) for total fruits, and 1.02 (95% CI: 0.99, 1.06) for total vegetables. Associations were similar for men and women separately and across studies. These results suggest that fruit and vegetable intake during adulthood is not associated with a reduced pancreatic cancer risk.

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Available from: Graham G Giles, Jan 05, 2016
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    • "Thus identification of novel pharmacological agents to overcome adverse effects of targeted therapies remains a major clinical challenge in the field. Active pharmacological agents isolated from fruits and vegetables have been reported to exhibit protective effects against many human cancers, such as breast cancer, bladder cancer, pancreatic cancer, and MM [7] [8] [9] [10]. Isoprenoids are one class of phytochemicals which play a critical role in the negative regulation of cell proliferation, apoptosis, and differentiation [11] [12]. "
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    • "Among specific components of the Mediterranean diet, vegetables and fruits have been reported to reduce the risk of pancreatic cancer in a few studies, possibly on account of their high content in vitamin C, folate, and phenolic compounds (Larsson et al, 2006; World Cancer Research Fund and American Institute for Cancer Research, 2007; Nothlings et al, 2007b; Hart et al, 2008; Bae et al, 2009; Rossi et al, 2012). However, the evidence is not consistent and a recent report of the World Cancer Research Association has judged the evidence for fruit and vegetables on pancreatic cancer ‘limited–not conclusive' (Koushik et al, 2012; World Cancer Research Fund and American Institute for Cancer Research, 2012). "
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