Spectrophotometric and spectrofluorometric methods for the determination of non-steroidal anti-inflammatory drugs: A review

Arabian Journal of Chemistry (Impact Factor: 3.73). 01/2011;


Non-steroidal anti-inflammatory drugs (NSAIDs) are the group most often used in human and veterinary medicine, since they are available without prescription for treatment of fever and minor pain. The clinical and pharmaceutical analysis of these drugs requires effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related jour-nals has been conducted and the instrumental analytical methods which were developed and used for determination of some non-steroidal anti-inflammatory, coxibs, arylalkanoic acids, 2-arylpropi-onic acids (profens) and N-arylanthranilic acids (fenamic acids) in bulk drugs, formulations and biological fluids have been reviewed. This review covers the time period from 1985 to 2010 during which 145 spectrophotometric methods including UV and derivative; visible which is based on for-mation of metal complexation, redox reactions, ion pair formation, charge-transfer complexation and miscellaneous; flow injection spectrophotometry as well as spectrofluorometric methods were

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Available from: Mohamed_kotb Kotb-El-Sayed
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    ABSTRACT: Objective: Three sensitive, selective, and precise spectrophotometric methods based on manipulation of ratio spectra, have been developed and validated for the determination of diclofenac sodium and pantoprazole sodium. Materials and methods: The first method is based on ratio spectra peak to peak measurement using the amplitudes at 251 and 318 nm; the second method involves the first derivative of the ratio spectra (Δλ = 4 nm) using the peak amplitudes at 326.0 nm for diclofenac sodium and 337.0 nm for pantoprazole sodium. The third is the method of mean centering of ratio spectra using the values at 318.0 nm for both the analytes. Results: All the three methods were linear over the concentration range of 2.0-24.0 μ g/mL for diclofenac sodium and 2.0-20.0 μg/mL for pantoprazole sodium. The methods were validated according to the ICH guidelines and accuracy, precision, repeatability, and robustness are found to be within the acceptable limit. The results of single factor ANOVA analysis indicated that there is no significant difference among the developed methods. Conclusions: The developed methods provided simple resolution of this binary combination from laboratory mixtures and pharmaceutical preparations and can be conveniently adopted for routine quality control analysis.
    Full-text · Article · Feb 2014 · The Scientific World Journal