Indication for Spinal Fusion and the Risk of Adjacent Segment Pathology: Does Reason for Fusion Affect Risk? A Systematic Review

*Department of Orthopaedic Surgery, University of Washington Medical Center, Seattle, WA †Spectrum Research, Inc., Tacoma, WA ‡Departments of Rehabilitation Medicine, Orthopaedic Surgery and Sports Medicine, and Neurological Surgery, University of Washington, Seattle, WA §Department of Orthopaedic Surgery, Harborview Medical Center, WA.
Spine (Impact Factor: 2.3). 08/2012; 37(22 Suppl):S40-51. DOI: 10.1097/BRS.0b013e31826ca9b1
Source: PubMed


STUDY DESIGN.: A systematic review. OBJECTIVE.: To determine whether different indications or reasons for spinal fusion are associated with different risks of subsequent adjacent segment pathology (ASP) in the lumbar and cervical spine. SUMMARY OF BACKGROUND DATA.: Pre-existing degeneration at levels adjacent to an arthrodesis may play a role in the development of symptomatic adjacent segment pathology. Although most spinal arthrodeses occur in patients with degenerative spinal disease, spinal fusion occurs in the pediatric and trauma population, and also congenitally. Evaluating the risk of ASP in these populations may shed light on its etiology. METHODS.: A systematic search was conducted in PubMed and the Cochrane Library for articles published between January 1, 1990, and December 31, 2011. We included all articles that described the risk of radiographical adjacent segment pathology (RASP) following surgical fusion for degenerative disease, for trauma, or for conditions requiring fusion in pediatrics in the lumbar or cervical spine. In addition, we included studies recording ASP in patients with congenital fusion. RESULTS.: Nineteen studies met our inclusion criteria. In patients who underwent fusion in the lumbar spine for degenerative reasons, the RASP rate averaged 12.4% during an average of 5.6-year follow-up. For patients who underwent fusion in the cervical spine for degenerative reasons, the average RASP rate was 25.3% during a 2.3-year follow-up. For patients with Klippel-Feil syndrome and congenital fusion, the RASP rate averaged 49.7% during an average of 23.5-years of follow-up. In patients who were fused for scoliosis, the average RASP rate was 20.3% of 3.9-year follow-up. However there is significant variation between studies in patient population, follow-up, and definition of RASP. CONCLUSION.: In the cervical spine, the rate of RASP in patients with fusion for degenerative reasons indications is greater than the rate of RASP in patients with congenital fusion suggesting that the pre-existing health and status of the adjacent level at the time of fusion may play a contributory role in the development of ASP. There is insufficient evidence in the literature to determine whether the indication/reason for fusion affects the risk of RASP in the lumbar spine CONSENSUS STATEMENT: In the cervical spine, the rate of RASP in patients with fusion for degenerative reasons indications is greater than the rate of RASP in patients with congenital fusion suggesting that the pre-existing health and status of the adjacent level at the time of fusion may play a contributory role in the development of ASP.Strength of Statement: Weak.

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    • "The short-term results of these techniques were usually good [8] [9] [10] [11]. However, Lee et al. reported that the long-term effect of cervical fusions in young children was associated with development of adjacent segment degeneration [19]. They also mentioned that the cumulative incidence of radiographical spine degeneration in the paediatric population ranged from 3% to 46% during a 2-to 7-year follow-up period. "
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