Transplantation: Is donor T-cell engraftment a biomarker for tolerance?

ArticleinNature Reviews Nephrology 8(10):560-1 · August 2012with6 Reads
Impact Factor: 8.54 · DOI: 10.1038/nrneph.2012.187 · Source: PubMed


    The link between chimerism and tolerance is well established. In a rhesus macaque study, Ramakrishnan et al. show that the type of chimerism might have an important effect on tolerance to kidney allografts, pointing to a critical role of donor T-cell production for success. These findings could directly impact clinical efforts to induce tolerance to allografts.