Highly selective fluorescence turn-on sensing of gold ions by a nanoparticle generation/C-I bond cleavage sequence

Department of Chemistry, Institute of Nanosensor and Biotechnology, Dankook University, 126 Jukjeon-dong, Yongin-si, Gyeonggi-do 448-701, Korea.
The Analyst (Impact Factor: 4.11). 08/2012; 137(19):4411-4. DOI: 10.1039/c2an35351b
Source: PubMed


We have developed a quickly responsive, and specific fluorescent assay for the detection of Au(III) on the basis of the formation of gold nanoparticles in the presence of HEPES, which cleave the C-I bond of I-BODIPY 1 to yield the highly fluorescent H-BODIPY 2.

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Available from: Jihye Park, Dec 08, 2014
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    • "Fluorimetry, in conjunction with suitable probes, is a preferable approach for the detection of trace levels of metal ions because this fluorescence-based method can be performed rapidly, is nondestructive , highly sensitive, and can provide real information on the localization and quantity, which is crucial to elucidate the functions of metal ions in biological systems [18] [19] [20] [21] [22]. To date, several gold ion-selective molecular probes based on various fluorophores such as rhodamine [23] [24] [25] [26] [27] [28] [29] [30], fluorescein [31] [32], BODIPY [33] [34] [35], naphthalimide [36] [37], coumarine [38] [39] [40], rhodamine- BODIPY coupling [41] [42] etc., have been reported. As a classic fluorophore, fluorescein possesses advantages such as good water solubility, visible excitation and emission, and maximum brightness at physiological pH [43]. "
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