Replication origins run (ultra) deep

Department of Biological Science, Florida State University, Tallahassee, Florida, USA.
Nature Structural & Molecular Biology (Impact Factor: 13.31). 08/2012; 19(8):740-2. DOI: 10.1038/nsmb.2352
Source: PubMed


The search for the holy replicator has been revitalized through ultradeep sequencing of small RNA-primed single-stranded DNA. Saturation sequencing provides an explanation for the lack of overlap in prior data sets, suggests that frequency of origin usage but not site selection is developmentally regulated, and uncovers a complex four-stranded DNA structure associated with most origins.

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Available from: David M Gilbert, Dec 29, 2014
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