Surveillance of Transmitted HIV Drug Resistance Using Matched Plasma and Dried Blood Spot Specimens From Voluntary Counseling and Testing Sites in Ho Chi Minh City, Vietnam, 2007-2008

Department of Health and Human Services/US Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Clinical Infectious Diseases (Impact Factor: 8.89). 05/2012; 54 Suppl 4(suppl 4):S343-7. DOI: 10.1093/cid/cir1049
Source: PubMed


During 2007–2008, surveillance of transmitted human immunodeficiency virus (HIV) drug resistance (TDR) was performed following
World Health Organization guidance among clients with newly diagnosed HIV infection attending voluntary counseling and testing
(VCT) sites in Ho Chi Minh City (HCMC), Vietnam. Moderate (5%–15%) TDR to nonnucleoside reverse-transcriptase inhibitors (NNRTIs)
was observed among VCT clients aged 18–21 years. Follow-up surveillance of TDR in HCMC and other geographic regions of Vietnam
is warranted. Data generated will guide the national HIV drug resistance surveillance strategy and support selection of current
and future first-line antiretroviral therapy and HIV prevention programs.

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    • "The overall high ambiguous mutation index (18.32×10-3 nts/site) similar to the one found in the Nigeria baseline dataset was somewhat not surprising because in Vietnam the two highest HIV risk groups were IDUs and commercial sex workers [39,42] and the subjects in the Vietnam HIVDR-TS were enrolled at VCT [28,30]. In contrast, those from other HIVDR-TS surveys except for China were enrolled at ANC clinics. "
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