Water-Soluble Poly(L-serine)s with Elongated and Charged Side-Chains: Synthesis, Conformations, and Cell-Penetrating Properties

Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
Biomacromolecules (Impact Factor: 5.75). 08/2012; 13(9):2609-15. DOI: 10.1021/bm3009445
Source: PubMed


Water-soluble poly(l-serine)s bearing long side-chain with terminal charge groups were synthesized via ring-opening polymerization of O-pentenyl-l-serine N-carboxyanhydride followed by thiol-ene reactions. These side-chain modified poly(l-serine)s adopt β-sheet conformation in aqueous solution with excellent stability against changes in pH and temperature. These water-soluble poly(l-serine) derivatives with charged side-chain functional groups and stable β-sheet conformations showed membrane-penetrating capabilities in different cell lines with low cytotoxicity.

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Available from: Haoyu Tang, Apr 22, 2014
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