Case Scenario: Perioperative Administration of Tocotrienols and Green Tea Extract in a Child with Familial Dysautonomia

Department of Anesthesiology and Critical Care Medicine, Perelman School of Medicine at the University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4399, USA.
Anesthesiology (Impact Factor: 5.88). 07/2012; 117(3):639-45. DOI: 10.1097/ALN.0b013e318267084d
Source: PubMed
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    ABSTRACT: The incidence of childhood neurodevelopmental disorders, which include autism, attention deficit hyperactivity disorders, and apraxia, are increasing worldwide and have a profound impact on these individuals’ behaviors, cognitive skills, mood and self-esteem. While the etiology of these disorders are unclear, they often accompany genetic and biochemical abnormalities resulting in cognitive and communication difficulties. Because cognitive and neural development require essential fatty acids (particularly long chain ω-3 fatty acids often lacking in mother’s and children’s diets) during critical growth periods, the potential behavior-modifying effects of these fatty acids as “brain nutrients” has attracted considerable attention. Additionally, there is compelling evidence for increased oxidative stress, altered antioxidant defenses, and neuroinflammation in these children. The purpose of this commentary is to provide a scientific rationale based upon cellular, experimental animal model, observational and clinical intervention studies for incorporating the combination of ω-3 fatty acids and tocotrienol-rich vitamin E as complementary nutritional therapies in children with neurodevelopmental disorders. Should this nutritional combination correct key clinical or biochemical outcomes and/or improve behavioral patterns, it would provide a safe, complementary option for these children.
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    ABSTRACT: Green tea processed from Camellia sinensis leaves is a common beverage with enormous medicinal importance. The accumulating evidences derived from in vitro, animal studies and human trials say loud for its diverse therapeutic potentials. The polyphenol rich tea extract has been validated to offer benefits as cancer prevention, amelioration of diabetes side-effects, cardiovascular safety, cognitive boost, promotion of weight loss, skin care, allergy suppression, protection from osteoarthritis, prebiotics etc. The flavanols, epigallocatechin gallate (EGCG) and epigallocatechin (EGC) have been identified to confer most of the biological effects. This review has been composed to keep track of the recent breakthroughs in this rapidly evolving area of dietary supplements. Mechanisms of functionality have been mentioned where ever deemed essential.
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