Thalidomide for the Treatment of Myelodysplastic Syndrome in Taiwan: Results of a Phase II Trial

Department of Internal Medicine, Changhua Christian Hospital, Taiwan, R.O.C.
Anticancer research (Impact Factor: 1.83). 08/2012; 32(8):3415-9.
Source: PubMed


Thalidomide inhibits angiogenesis and exerts complex immunomodulatory activities. This phase II study aimed to examine the efficacy of thalidomide in Taiwanese patients with myelodysplastic syndrome (MDS).
Sixty patients [intention to treat group (ITT)] with MDS were treated with thalidomide (100 mg/day, increased by 100 mg/day weekly to a maximum of 400 mg/day) for 12 weeks. Forty-two patients of the ITT group were considered as comprising the evaluable population (EP).
Thalidomide resulted in hematological improvement (HI) in 28% of ITT analysis and in HI in 40% of the EP. Thalidomide was more effective for MDS patients with low to intermediate-1 International Prognostic Score System scores. The response rates were 7% for ITT and 10% for EP patients. Only two patients exhibited a cytogenetic response. Net reduced levels of vascular endothelial growth factor and basic fibroblast growth factor cytokines were observed in the peripheral blood and the bone marrow of thalidomide-treated patients.
Low-dose thalidomide is an effective and safe treatment for patients with low-risk MDS.

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Available from: cheng-shyong Chang, Feb 19, 2015
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    • "Regimen No patients RR% low risk MDS RR% high risk MDS Reference CsA 50 62 40 Shimamoto et al. [74] eATG 25 64 33 Molldrem et al. [75] eATG 96 47 7 Lim et al. [10] eATGþ/CsA 129 37 23 Sloand et al. [7] eATG þ CsA 45 21 19 Passweg et al. [76] anti CD52 29 77 57 Sloand et al. [9] cA2 37 22 ND Raza et al. [77] cA2 10 20 ND Boula et al. [58] Len 148 76 (del 5q) ND List et al. [78] Len 214 43 (non del 5q) ND Raza et al. [79] Len 47 ND 27 Adès et al. [80] Thal 7 50 0 Invernizzi et al. [81] Thal 42 50 0 Chung et al. [82] Anti CD52: Alemtuzumab; eATG: Equine anti thymocyte globulin; cA2: Infliximab; CsA: Cyclosporine; Len: Lenalidomide ND: Not determined; RR: Response rate; Thal: Thalidomide. "
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