Spontaneous pneumothorax occurring as a complication of the antitumor effect of cytotoxic chemotherapy has been reported in occasional cases of osteogenic sarcoma. Its occurrence in other tumors has not been described. This report describes two cases of this complication in patients with germinal tumors and discusses possible pathophysiologic mechanisms.
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"It is estimated that less than 1% of all SP are tumor-associated  . Metastatic osteogenic or soft tissue sarcoma are most commonly associated with pneumothorax, particularly in the setting of administration of cytotoxic chemotherapy   or radiation . In the majority of these previously reported cases, the patients either had known metastatic pulmonary disease or the diagnosis was rapidly suggested by nodules detected by imaging modalities. "
[Show abstract][Hide abstract] ABSTRACT: We present two cases of spontaneous pneumothorax secondary to metastaticsynovial cell sarcoma. Radiographic techniques initially
did not suggestlung nodules in either patients; thoracoscopy allowed sequential bilateraldetection of small pulmonary metastases
in one case and confirmed thediagnosis during treatment of recurrent pneumothorax in the second case.This report underlines
that pneumothorax may be the first clinicalmanifestation of metastatic sarcoma and can occur even if current imagingtechniques
are not indicative of metastatic disease. In the latterinstance, thoracoscopic exploration has to be envisaged in order to
ruleout the possibility of metastatic lung involvement.
Preview · Article · Jul 1997 · European Journal of Cardio-Thoracic Surgery
[Show abstract][Hide abstract] ABSTRACT: Two patients with pulmonary metastases from synovial sarcoma and germ-cell tumor developed first bilateral, then repeated unilateral pneumothoraces during combination chemotherapy. It is suggested that chemotherapy may occasionally cause pneumothorax.